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ProteomicsFlexible B12 ecophysiology of Phaeocystis antarctica due to a B12-independent methionine synthase fusion protein with widespread homologues
Coastal Antarctic marine ecosystems play an important role in carbon cycling due to their highly productive seasonal phytoplankton blooms. Southern Ocean microbes are primarily limited by light and iron (Fe) and can be co-limited by cobalamin (vitamin B12 ). Micronutrient limitation is a key driver ...
ORGANISM(S): Phaeocystis antarctica 
2023-02-27 | PXD031524 | Pride
Lc-msms Vitamin b12 Phaeocystis antarctica Methionine synthase fusion protein 
UnknownRestricted role for methionine synthase reductase defined by subcellular localization.
Not available
S-EPMC2765244 | biostudies-literature
ProteomicsMultiomics approach to decipher pathophysiological mechanisms and therapeutic impact of methionine restriction in cystathionine β-synthase deficient homocystinuria
Background. Cystathionine β-synthase (CBS)-deficient homocystinuria (HCU) is an inherited disorder of sulfur amino acid metabolism with varying severity and organ complications, and a limited knowledge about underlying pathophysiological processes. Here we aimed at getting an in-depth insight into d...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD049417 | Pride
Cystathionine beta-synthase  homocystinuria  methionine restriction  metabolomics  proteomics 
UnknownFlexible B12 ecophysiology of Phaeocystis antarctica due to a fusion B12-independent methionine synthase with widespread homologues.
Not available
S-EPMC10861871 | biostudies-literature
ProteomicsProtein Succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity
The cytokines tumor necrosis factor ligand superfamily member 11 (TNFSF11; also known as RANKL) and macrophage colony-stimulating factor 1 receptor (M-CSF) differentiate macrophages into bone-resorbing osteoclasts via a process characterised by changes in metabolic activity that support energy-consu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD060675 | Pride
Succinylation Post translational modification Steoclast Citrate synthase Rankl 
ProteomicsA bioorthogonal chemical reporter for fatty acid synthase-dependent protein acylation
Mammalian fatty acid synthase (FASN) is a lipogenic enzyme that catalyzes the formation of the long chain saturated fatty acid palmitate from acetyl and malonyl CoA in the presence of NADPH. Mammalian cells acquire fatty acids through dietary sources or through FASN. Although most mammalian cells ex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028244 | Pride
Fatty acid synthase N-myristoylation Protein acylation Click chemistry S-palmitoylation 
ProteomicsPurified Porcine ATP synthaseLCMSMS
Purified mitochondrial ATP synthase has been shown to form Ca2+-activated, large conductance channel activity similar to that of mitochondrial megachannel (MMC) or mitochondrial permeability transition pore (mPTP) but the oligomeric state required for channel formation is being debated. We reconstit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-01-13 | PXD016255 | Pride
Porcine Atp synthase 
TranscriptomicsIdentification of ETO2-GLIS2 transcriptional targets
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-05 | E-MTAB-4332 | biostudies-arrayexpress
ProteomicsMethionine stress induces ferroptosis in methionine dependent cancer cells
Dietary methionine restriction is associated with a reduction in tumor growth in preclinical studies and an increase in lifespan in animal models. The mechanism by which methionine restriction inhibits tumor growth while sparing normal cells is incompletely understood, except for the observation tha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-07 | MSV000091423 | MassIVE
ProteomicsMitochondrial translocase blocking ATP5MG-tFT fusion protein interactome in human embryonic kidney (HEK) 293 cells
The experiment uses HEK-293 Flp-In T-Rex cells to express fusion protein that combines ATP synthase subunit ATP5MG with a tandem fluorescent protein timer (tFT). The tFT tag combines mCherry and super folder GFP (sfGFP) fluorescent proteins. An exceptionally stable structure of sfGFP interferes with...
ORGANISM(S): Homo sapiens (Human) 
2024-03-08 | PXD038583 | Pride
Translocase of the outer mitochondrial membrane Protein import Quality control Mitochondria Translocation 
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