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ProteomicsHigh throughput and automated platform for MHC peptides purification
We developed a novel high-throughput and automated platform for MHC (major histocompatibility complex) peptides purification using AssayMAP with enhanced speed, sensitivity and reproducibility relative to prior studies.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD022629 | Pride
Mhc immunoprecipitation automation 
ProteomicsComparison of the MHC I immunopeptidome repertoire of B-cell lymphoblasts using two isolation methods
Significant technological advances in both affinity chromatography and mass spectrometry have facilitated the identification of peptides associated with the major histocompatibility complex class I (MHC I) molecules, and enabled a greater understanding of the dynamic nature of the immunopeptidome of...
ORGANISM(S): Homo sapiens (Human) 
2018-03-09 | PXD007935 | Pride
B-cell Human Ip Mips Mhc i-associated peptides Mae 
ProteomicsCharacterization of HLA-A*02:01 MHC Immunopeptide Antigens Enhanced by Ultraviolet Photodissociation Mass Spectrometry
Triplicate results for 193 nm UVPD, HCD, and EThcD of a mixture of 157 synthetic peptide mixture, and 193 nm UVPD, HCD, and EThcD of BB7.2 and W6/32 immunoprecipitations
ORGANISM(S): Homo Sapiens (human) 
2021-08-13 | PXD027830 | JPOST Repository
ProteomicsRole for ribosomal quality control in sampling proteins for MHC class I-mediated antigen presentation
Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes. MHC-I peptides originate from protein degradation by the proteasome, suggesting that efficiently-folding, long-lived proteins could evade monitoring. H...
ORGANISM(S): Homo sapiens (Human) 
2020-01-29 | PXD014644 | Pride
Ribosomal quality control Listerin Immunopeptidome Mhc-i 
ProteomicsMapping of immunopeptidome of cancer immunotherapy with oncolytic virus and checkpoint blockade
The elucidation of therapy-induced changes to the class I major histocompatibility complex (MHC-I)-bound tumor antigens is crucial for understanding immune-mediated tumor eradication and identifying potential targets for peptide vaccines to enhance the efficacy of immunotherapies. Here, we investiga...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD024369 | Pride
Antitumor immunity Mhc immunoprecipitation Immune checkpoint blockade Oncolytic virus Lc-sps-ms3 Murine Fibrosarcoma Lc-ms/ms 
OtherAssessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.
Data from ProteomeXchange, PXD ID: PXD002534. File: GR_130129_20_OT3_NT_L3MBTL2_FAB_31_G11_2_HEK293.mzXML. Published as part of Nat Methods. 2015 Jun 29 . From the Abstract: {{i}} ... We describe a mass spectrometry-based standard operating procedure for scoring immunoprecipitation antibody quality...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320016573 | GPMDB
Resource Reanalysis 
ProteomicsThe Mycobacterium tuberculosis ESX-1 secretion system controls antigen presentation on MHC-I in human macrophages
Mycobacterium tuberculosis (Mtb) remains one of the world’s leading infectious killers. Although CD8⁺ T cells contribute to immune control of tuberculosis, the pathways through which bacterial antigens access major histocompatibility complex class I (MHC-I) antigen presentation remain incompletely d...
ORGANISM(S): Mycobacterium tuberculosis Homo sapiens (Human) 
2026-09-30 | PXD084949 | Pride
Host-pathogen interactions Tuberculosis Mhc Immunopeptidomics 
ProteomicsImmunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design
No currently licensed vaccine reliably prevents pulmonary tuberculosis, a leading cause of infectious disease mortality with a growing rate of extensive drug resistance. Developing effective new vaccines will likely require identifying Mycobacterium tuberculosis (Mtb)-derived antigens presented on M...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD055952 | Pride
Dendritic cells Tuberculosis Mhc class ii Human Immunopeptidomics 
ProteomicsMHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection
We sought to build a catalog of epitopes presented by breast cancers using a renewable resource of well-characterized breast cancer cell lines. Starting from 70 breast cancer cell lines, we measured MHC class I abundance and used pre-existing RNAseq data to identify either HLA-A*02 or MHC class I-po...
ORGANISM(S): Homo sapiens (Human) 
2018-01-16 | PXD006406 | Pride
Immune system Mass spectrometry Human Mhc class 1 ligands Hla typing Peptide sequencing Breast cancer Cell lines Immunoprecipitation Rna-seq 
ProteomicsIdentification of blood MHC-binding peptides in mice after Brucella infection
We infected mice with Brucella, took mouse blood 6 days after infection, MHC binding antigenic peptides were collected by immunoprecipitation method and verified by mass spectrometry
ORGANISM(S): Mus Musculus 
2022-03-27 | PXD032855 |
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