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ProteomicsSmall molecule-induced polymerization triggers degradation of BCL6
Most small-molecule protein degraders act as interface stabilizers ‘molecular glues’ between E3 ubiquitin ligases and target proteins to induce ternary complex formation and ubiquitin-dependent target protein degradation. Here we report polymerization as a novel mechanism for small molecule-induced ...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD016185 | Pride
Polymerization Bcl6 Molecular glue Siah1 Ubiquitin Btb Dlbcl 
ProteomicsUBR5 Forms Ligand-Dependent Complexes on Chromatin to Regulate Nuclear Hormone Receptor Stability
Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Hormone binding triggers NR activation and their subsequent proteasomal degradation through unknown ligand-dependent ubiquitin ligase machinery. NR degradation is therapeutically releva...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040953 | Pride
Nuclear receptors Ubr5 Degradation Hormones Chromatin 
GenomicsWhole Genome Association Study of Bipolar Disorder

The goal of the project is to identify genes that make individuals more susceptible to bipolar disorder (manic depressive illness) and to better understand the brain pathways involved in the disease.

Dataset versioning

  • Version 1: European-American (EA) ancestr...
phs000017.v3.p1 | EGA
UnknownA randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.
Not available
S-EPMC5224719 | biostudies-literature
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