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ProteomicsProteomic Analysis of a PLK1-Dependent, Cell Cycle Degradation Program
Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCFβTrCP. However, the magnitu...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046039 | Pride
Degradation Plk1 Cell cycle Ubiquitin 
ProteomicsIdentification of SAFB and HnrnpU interactors
Scaffold Attachment Factor B (SAFB) is a conserved RNA Binding Protein (RBP) that is essential for early mammalian development. However, the RNAs that associate with SAFB in mouse embryonic stem cells have not been characterized. Here, we addressed this unknown using RNA-seq and SAFB RNA immunopreci...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD038103 | Pride
Stem cell Development Rna binding proteins 
ProteomicsProteomic profiling of Palbociclib arrested cells ± APC/C inactivation.
Cellular proliferation is highly regulated to ensure proper tissue homeostasis and to prevent diseases such as cancer. In actively proliferating cells, entry into S phase of the cell cycle and initiation of DNA replication is promoted by inactivation of the E3 ubiquitin ligase APC/C (anaphase promot...
ORGANISM(S): Homo sapiens (Human) 
2024-07-18 | PXD046783 | Pride
Cancer Palbociclib Cell cycle Apc/c 
ProteomicsThe synaptic proteome and phosphoproteome is uniquely vulnerable to sleep loss during brain development while maturation confers resilience
Sleep supports lifelong brain health and cognition. Sleep loss in early life can drive lasting changes in adult behavior, indicating sleep plays a distinct but poorly understood role supporting brain development. We systematically examined the molecular and behavioral adaptations and synaptic conseq...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-08 | PXD047381 | Pride
Synapses  brain development  sleep  sleep deprivation 
ProteomicsProteomic analysis of Eya3 binding partners
Eyes absent homolog 3 (EYA3) is a transcriptional cofactor that is known to partner with the sine oculis homeobox (SIX) family to regulate gene expression. In this study, we characterized a novel splice isoform of EYA3, including the alternative cassette exon 7 (EYA3+ex7), that becomes more highly e...
ORGANISM(S): Homo sapiens (Human) 
2023-10-13 | PXD037572 | Pride
Transcription Eya3 Alternative splicing Myogenesis 
ProteomicsIdentification of TBC1D30 interactors in murine MIN6 insulinoma cells.
Components of the insulin processing and secretion pathways remain incompletely understood. Here we examined a genome-wide association study (GWAS) locus associated with plasma proinsulin levels. Low-frequency GWAS variant rs150781447 encodes an Arg279Cys substitution in TBC1D30, but no role for thi...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-06-08 | PXD047652 | Pride
Proinsulin  insulin  secretion  genome-wide association study  rab gtpase activating protein Affinity purification-mass spectrometry 
ProteomicsThe Valine-Arginine dipeptide repeat protein encoded by mammalian telomeric RNA appears highly expressed in mitosis and may repress global translation
Translation of mammalian telomeric G-rich RNA via the Repeat Associated non-AUG translation mechanism can produce two dipeptide repeat proteins: repeating valine-arginine (VR) and repeating glycine-leucine (GL). Their potentially toxic nature suggests that to be retained through evolution, one or bo...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD054040 | Pride
Rna binding Mitosis Translation. Vr dipeptide 
ProteomicsFOXA1 proximity labeling reveals novel interactions with NR2C2 in ER+ breast cancer
Approximately 75% of breast cancers are driven by the estrogen receptor alpha (ER), and despite the advent of endocrine therapy to block ER signaling pathways, a significant portion of women develop resistance to these drugs. The pioneer factor FOXA1 has been shown to facilitate nearly all DNA-bindi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD046652 | Pride
Nr2c2 Biotin ligase Foxa1 Proximity labeling Breast cancer 
ProteomicsSCFCyclin F targets the metabolic protein Sirtuin 5 for ubiquitination
Cell cycle transitions are regulated by a number of coordinating signaling events. The ubiquitin-proteasome system is an important part of this cell cycle signaling. Cyclin F, a substrate adapter for the SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase, is an important regulator of cell cycle progression. ...
ORGANISM(S): Homo Sapiens (human) 
2020-11-17 | PXD019396 | JPOST Repository
UnknownIsradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial.
Not available
S-EPMC7465126 | biostudies-literature
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