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ProteomicsAlzheimer’s disease risk and the isoform dependence of phospholipid-apolipoprotein E interaction
The ε4 allele of the APOE gene, encoding the E4 isoform of apolipoprotein E, is the leading genetic risk factor for late-onset Alzheimer’s disease. While many potential mechanisms have been proposed to explain this risk, no dominant or unifying process has yet emerged. Here, we explore the primary f...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD068681 | Pride
Csp Proteomics Ms Apoe Lipids Plasmalogen 
Proteomics2D Spatial Proteomic Mapping Shows Distinct Regional Differences in the Bovine Cardiac Proteome
This study highlights that organs can have variable sub-proteomes that do not necessarily correspond to anatomical features. The bovine heart as a model demonstrates at least 3-5 separate proteomes exist within a 2D plane of the heart. The main differences between these proteomes were the biochemica...
ORGANISM(S): Bos taurus (Bovine) 
2024-10-17 | PXD013375 | Pride
Heart Desmoglein 2 Proteomics Bovine Mitochondria Proteome 
ProteomicsDevelopment a of novel targeted proteomic plasma biomarker panel for hypertrophic cardiomyopathy
Rationale There is a need for new and better biomarkers for hypertrophic cardiomyopathy (HCM) which correlate more closely with disease progression as determined by clinical imaging and biohumoral information. We have used a combination of heart tissue and plasma proteomics to identify potential bi...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD009859 | Pride
Human Lc-msms Hypertrophic cardiomyopathy Heart Plasma 
ProteomicsA Proteomic Analysis of the Myocardium in Hypertrophic Obstructive Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is characterised by a complex phenotype that is only partly explained by the biological effects of individual genetic variants. The aim of this study was to use proteomic analysis of myocardial tissue to explore thepostgenomic phenotype.
ORGANISM(S): Homo sapiens (Human) 
2019-08-14 | PXD011994 | Pride
Hypertrophic cardiomyopathy fibrosis proteomics 
ProteomicsPlasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection
The majority of those infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the first wave did not require hospitalisation. Most had a short-lived mild or asymptomatic infection, while others had symptoms that persisted for weeks or months. We performed a longitudinal targe...
ORGANISM(S): Homo sapiens (Human) 
2022-10-11 | PXD036590 | Pride
Covid-19 Lc-msms Long-covid Plasma 
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsAn epithelial-mesenchymal transition (EMT) gene signature predicts resistance to erlotinib and PI3K pathway inhibitors and identifies Axl as a novel EMT marker in non-small cell lung cancer.
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-33072 | biostudies-arrayexpress
ProteomicsA new multiplexed plasma biomarker panel developed using targeted proteomics and machine learning has diagnostic and prognostic potential in children with hypertrophic cardiomyopathy
Background Hypertrophic cardiomyopathy (HCM) is defined clinically by pathological left ventricular hypertrophy (LVH). We have previously developed a plasma proteomics biomarker panel that correlates with clinical markers of disease severity and sudden cardiac death (SCD) risk in adult patients with...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD045304 | Pride
Childhood-onset hcm proteomics 
Proteomics‘The long tail of Covid 19’ - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients
‘Long Covid’ or medical complications associated with a post SARS Covid 2 infection, are a significant post-viral complication that is being more and more commonly reported in patients. Therefore, there is an increasing need to understand the disease mechanisms, identify drug targets and inflammato...
ORGANISM(S): Homo Sapiens 
2021-01-21 | PXD022159 | panorama
MetabolomicsImpact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights
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