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ProteomicsPachycladon Shotgun Proteomics
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ORGANISM(S): Pachycladon(Exile) Pachycladon(cheesemanii) Pachycladon(Enysii) Pachycladon(Fastigiatum) Pachycladon(novaezelandiae) 
2011-01-28 | PRD000187 | Pride
ProteomicsY chromosome-located gene, lysine-specific demethylase 5D, associated with prostate cancer
The objective of Human Y Chromosome Proteome Project is to map and annotate all proteins encoded by genes on the MSY sequences. Lysine (K)-specific demethylase 5D (KDM5D) is located on the AZFb region of Y chromosome and encode for a JmjC-domain-containing protein. Changes in KDM5D transcript level ...
ORGANISM(S): Homo sapiens (Human) 
2015-08-05 | PXD000416 | Pride
Label-free shotgun proteomics Human y chromosome Kdm5d 
ProteomicsEnrichment, proteome analysis and transplantation of human embryonic stem cell derived dopaminergic progenitors expressing LMX1a
Despite the progress in safety and efficacy of cell therapy with pluripotent stem cells (PSCs), the presence of residual undifferentiated stem cells or proliferating neural progenitor cells (NPCs) with rostral identity has remained a major challenge. Here we reported the generation of an LMX1A knock...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007837 | Pride
Parkinson disease Pluripotent stem cells Quantitative proteomics Hesc 
ProteomicsMouse Model of Alzheimer’s Disease Demonstrates Differential Effects of Early Pathology on Various Brain Regions
Alzheimer’s disease (AD) is a chronic ageing related neurodegenerative disease which is characterized by loss of synapses and neurons in the vulnerable brain regions. Expression perturbations of amyloid β (Aβ) and tau protein in the brain are two hallmarks of AD. Aβ is abnormally generated from amyl...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD019192 | Pride
Proteomics Hippocampus Alzheimer’s disease Cerebellum Amyloid beta Cortex App/ps1 
ProteomicsRetinal Pathological Features and Proteome Signatures of Alzheimer’s Disease
Alzheimer’s disease (AD) pathologies were discovered in the easily accessible neurosensory retina. Yet, their specific nature, topographical distribution, and relationship with disease status remain undefined. Here, we histologically determined burden and spatial distribution of amyloid β-protein (A...
ORGANISM(S): Homo sapiens (Human) 
2025-10-22 | PXD040225 | Pride
Proteomics Brain Alzheimer's disease Retina 
ProteomicsFingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy and neuroinflammatory networks
Fingolimod (FTY720) is an oral drug approved by the Food and Drug Administration (FDA) for management of Multiple Sclerosis (MS) symptoms, which has also shownbeneficial effects against Alzheimer’s (AD) and Parkinson’s (PD) diseases pathologies. Although an extensive effort has been made to identif...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-09 | PXD034427 | Pride
Fingolimod Brain Frontal cortex Cerebellum Proteomics 
ProteomicsManiupulating root water supply elicits major shifts in the shoot proteome
Detailed information: Rice (*Oryza sativa* L. cv. Nipponbare) is a drought-susceptible species which is well suited for studies of abiotic stress response because of the comprehensive bioinformatics resource available. By withholding water from the entire root system of young rice plants, or half th...
ORGANISM(S): Oryza sativa (Rice) 
2020-01-22 | PXD000319 | Pride
Split-root Drought Rice Shotgun proteomics 
ProteomicsDDX3Y and other Male Specific Region of Y Chromosome Genes may modulate neuronal differentiation and mediate various biological pathways in addition to their well described role regulating spermatogenesis
Human tissue based proteomics projects are challenging due to low abundance of proteins and tissue specificity of protein expression. In this study, we aimed to develop a cell-based approach to profile the male specific region of the Y chromosome (MSY) proteins. First, we profiled the expression of ...
ORGANISM(S): Homo sapiens (Human) 
2015-09-17 | PXD002428 | Pride
Rna metabolism. Chromosome centric human proteome project (c-hpp) Ddx3y Apoptosis Cell-based human proteome project Cell cycle Shotgun proteomics Y-linked genes 
ProteomicsPatient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of vision loss. Reticular pseudodrusen (RPD), deposits on the apical side of the retinal pigment epithelium (RPE), signify a distinctive and critical AMD phenotype. Yet, their molecular basis and relationship to the conventional drusen seen i...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD070797 | Pride
Human induced pluripotent stem cells  retinal pigment epithelium  single-cell rna sequencing  genome regulation  age-related macular degeneration  reticular pseudodrusen  transcriptomics  proteomics. 
ProteomicsTranscriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.
Induced pluripotent stem cells generated from patients with geographic atrophy as well as healthy individuals were differentiated to retinal pigment epithelium (RPE) cells. By integrating transcriptional profiles of 127,659 RPE cells generated from 43 individuals with geographic atrophy and 36 contr...
ORGANISM(S): Homo sapiens (Human) 
2022-06-01 | PXD029501 | Pride
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