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TranscriptomicsExpression data of A375 melanoma cells after DMSO or MLN4924 treatment from 1 hour to 24 hour
Microarrays were used to determine the change in gene expression of genes involved in the CDT1/NAE pathway A375 cells were grown and then incubated in the presence of either DMSO as control or 650nM MLN4924. Cells were treated for 1, 2, 4, 8, and 24 hours. RNA extraction and hybridization on Affymet...
ORGANISM(S): Homo sapiens 
2011-07-09 | E-GEOD-30531 | biostudies-arrayexpress
TranscriptomicsMLN4924 in chronic lymphocytic leukemia
CLL cells obtained from patients with CLL were treated with MLN4924 to determine whether NFkB transcription targets were affected by the drug. CLL cells were treated with 1 microM MLN4924 or vehicle control for 24 hours. Cells were collected by centrifugation and B-cell were purified using negative...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-44864 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of myeloma cells treated with NAE inhibitor
The transcriptional profile of the human multiple myeloma (MM) cell line MM.1S treated with MLN4924 vs control MM.1S cells was characterized by oligonucleotide microarray analysis, using the human U133 plus 2.0 Affymetrix GeneChip, according to previously described protocols for total RNA extraction...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-33577 | biostudies-arrayexpress
ProteomicsIdentification of substrates of the CRL4-HBx E3 ubiquitin ligase
Hepatitis B Virus (HBV) remains a major public health problem, and is a major cause liver cancer worldwide. HBV infection in vivo requires the function of the HBx protein, which facilitates expression of viral genes from the episomal genome by an unknown mechanism. Evidence suggests that HBx funct...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD004762 | Pride
Ubiquitylation Hbv Crl4 Cullin Substrate Hbx Mln4924 
GenomicsExpression data from ependymal cell cultures treated with MLN4924.
Expression data from ependymal cell cultures treated with MLN4924.
PRJNA436123 | ENA
GenomicsRNA-seq of macrophages treated with or without MLN4924
RNA-seq of macrophages treated with or without MLN4924
PRJNA1237321 | ENA
ProteomicsThe NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice
To investigate protein expression differences in the ischemic brain between mice treated with vehicle and MLN4924, high-throughput proteomics Liquid Chromatography-Mass Spectrometry (LC-MS)-based analysis was performed.
ORGANISM(S): Mus Musculus 
2021-11-25 | PXD029910 |
TranscriptomicsExpression data of A375 melanoma cells after DMSO or MLN4924 +/- Nutlin treatment for 26 hours
Microarrays were used to determine the change in gene expression of genes involved in the p53 pathway after siRNA knock down of p53, CDT1 or BRCA1 A375 cells were grown, transfected with siRNA, incubated for 48hrs, then incubated for another 26hrs in the presence of either 0.065% DMSO as control, 65...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-39091 | biostudies-arrayexpress
ProteomicsSystematic analysis of synergistic proteome modulations in a drug combination of cisplatin and MLN4924
Chemotherapeutic treatment regimens often take advantage of synergistic effects of drug combinations. Anticipating that synergistic effects on cell biological level likely manifest on proteome level, the analysis of proteome modulations represents an appropriate strategy to study drug combinations o...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD009185 | Pride
Human Synergy Lc-ms/ms 
TranscriptomicsMLN4924 in chronic lymphocytic leukemia
CLL cells obtained from patients with CLL were treated with MLN4924 to determine whether NFkB transcription targets were affected by the drug.
ORGANISM(S): Homo sapiens 
2013-03-05 | GSE44864 | GEO
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