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ProteomicsChemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader
Discovery of a covalent molecular glue degrader that covalently interacts with UBE2D and engages in molecular glue interactions with NFKB1
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039924 | Pride
Molecular glue degraders 
GenomicsTRI-611, a selective, brain-penetrant molecular glue degrader of ALK
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
PRJNA1459258 | ENA
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
ProteomicsDCAF11-dependent molecular glue degrader activated by glutathionylation
Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins. Here, we report an unbiased and broadly applicable platform for the systematic discovery of molecular g...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD067063 | Pride
E3 ligase Ddx18 Molecular glue Protein degradation Dcaf11 Gluthionylation 
ProteomicsDCAF11-dependent molecular glue degrader activated by glutathionylation
Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins. Here, we report an unbiased and broadly applicable platform for the systematic discovery of molecular g...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD067066 | Pride
E3 ligase Ddx18 Molecular glue Protein degradation Dcaf11 Gluthionylation 
ProteomicsDCAF11-dependent molecular glue degrader activated by glutathionylation
Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins. Here, we report an unbiased and broadly applicable platform for the systematic discovery of molecular g...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD067070 | Pride
E3 ligase Ddx18 Molecular glue Protein degradation Dcaf11 Gluthionylation 
ProteomicsDCAF11-dependent molecular glue degrader activated by glutathionylation
Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins. Here, we report an unbiased and broadly applicable platform for the systematic discovery of molecular g...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD067016 | Pride
E3 ligase Ddx18 Molecular glue Protein degradation Dcaf11 Gluthionylation 
ProteomicsDCAF11-dependent molecular glue degrader activated by glutathionylation
Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins. Here, we report an unbiased and broadly applicable platform for the systematic discovery of molecular g...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD067067 | Pride
E3 ligase Ddx18 Molecular glue Protein degradation Dcaf11 Gluthionylation 
UnknownChemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB.
Not available
S-EPMC10121878 | biostudies-literature
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047141 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
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