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TranscriptomicsMondoA is highly expressed in acute lymphoblastic leukemia and modulates metabolism, differentiation and survival
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted treatment of childhood ALL, we performed a comprehensive transcriptome analysis yielding a set of genes specifically overexpressed in ALL. Among them we identified MondoA - a transcripti...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-33967 | biostudies-arrayexpress
TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
UnknownMyc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice.
Not available
S-EPMC6153302 | biostudies-literature
GenomicsIntegrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β-cells
Glucose is an important regulator of pancreatic β-cell function. In addition to the acute stimulation of insulin secretion, glucose stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β-cells. The glucose-sensin...
ORGANISM(S): Rattus norvegicus 
2016-09-06 | E-GEOD-81628 | biostudies-arrayexpress
TranscriptomicsMondoA is highly expressed in acute lymphoblastic leukemia and modulates metabolism, differentiation and survival
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted treatment of childhood ALL, we performed a comprehensive transcriptome analysis yielding a set of genes specifically overexpressed in ALL. Among them we identified MondoA - a transcripti...
ORGANISM(S): Homo sapiens 
2012-08-01 | GSE33967 | GEO
TranscriptomicsCooperative Regulation of Normal and Neoplastic Hepatocyte Proliferation by Myc and ChREBP
By analogy to the c-Myc (Myc)/Max family of transcription factors, there also exists a “parallel” network of structurally and functionally related bHLH-ZIP proteins with certain Myc-like functions. Two closely related “Myc-like” paralogs termed Mondo A and MondoB/ChREBP (ChREBP) positively regulate ...
ORGANISM(S): Mus musculus 
2018-08-09 | GSE114634 | GEO
TranscriptomicsIntergrated expression profiling and ChIP-SEQ analyses of ChREBP-mediated glucose response network (expression data only)
We identified ChREBP-binding regions from the DNA of human hepatocellular targets as well as previously-known targets Total RNA from hepG2 cell line
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22074 | biostudies-arrayexpress
Transcriptomicsmicroarray analysis of bone marrow derived macrophages stimulated with helminth larvae and immune serum
Mouse bone marrow derived macrophages were stimulated with L3 larvae of the helminth Heligmosomoides polygyrus (Hp) (500 L3 /1 mio cells) in the presence or absence of immune serum (1:50 v:v) from challenge-Hp-infected mice.
ORGANISM(S): Mus musculus 
2013-12-31 | E-MEXP-3920 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of Arabidopsis sweet11/sweet12 double mutants upon Colletotrichum higginsianum infection
In compatible interactions, biotrophic microbial phytopathogens rely on the supply of carbon and nitrogen assimilates by the colonized host tissue. Successful biotrophs need to reprogram host metabolism, which also involves the stimulation of assimilate export from living host cells into the plant-p...
ORGANISM(S): Arabidopsis thaliana 
2016-03-31 | E-GEOD-67544 | biostudies-arrayexpress
ProteomicsSystematic genome perturbation reveals coordination of lipid droplets and metabolic gene regulation
Lipid droplets (LDs) store lipids for metabolic eneergy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012640 | Pride
Metabolism Chrebp Mlx Mondoa Mondob Transcription facot Mlxipl Lipid droplets Glucose Mlxip 
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