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ProteomicsFOX transcription factors are common regulators of Wnt/β-catenin signaling
The Wnt/β-catenin signaling pathway is a critical regulator of development and stem cell maintenance. Mounting evidence suggests that the context-specific outcome of Wnt signaling is determined by the collaborative action of multiple transcription factors, including members of the highly conserved f...
ORGANISM(S): Homo sapiens (Human) 
2023-04-19 | PXD038811 | Pride
Fox transcription factors Turboid Wnt signaling Lc-ms/ms 
ProteomicsWnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer
The Wnt signaling pathway is playing a crucial role during development and adult tissue homeostasis. However, the tissue and cell type-specific regulation of Wnt pathway activity remains incompletely understood. Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-16 | PXD015725 | Pride
Foxb2 Cancer Wnt Differentiation 
ProteomicsProximity proteomics of the oncoprotein β-catenin
-catenin affects human physiology and pathology through numerous interaction partners, of which many have been discovered by standard affinity purification-based proteomics. However, the interaction landscape of -catenin remains incompletely understood, highlighting a need for new experimental appro...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067416 | Pride
Β-catenin Proximity proteomics Turboid Bioid 
ProteomicsThe oncogenic transcription factor FOXQ1 is a bimodal regulator of Wnt target genes
The forkhead box transcription factor FOXQ1 is aberrantly induced in various cancers, and contributes to tumour growth and metastasis. It has been suggested that the oncogenic potential of FOXQ1 may be explained by its activation of the Wnt/β-catenin signalling pathway. However, the mode of action ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-05 | PXD035624 | Pride
Human Lc ms/ms Hek293t 
ProteomicsThe oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling
The forkhead box transcription factor FOXQ1 is aberrantly induced in various cancers, and contributes to tumour growth and metastasis. It has been suggested that the oncogenic potential of FOXQ1 may be explained by its activation of the Wnt/β-catenin signalling pathway.However, the mode of action of...
ORGANISM(S): Homo sapiens (Human) 
2022-10-05 | PXD030464 | Pride
Human Lc-msms 
ProteomicsMass spectrometry analysis of MTH1 inhibitor TH1579 in keratinocytes
MutT Homolog 1 (MTH1) prevents the incorporation of oxidized nucleotide triphosphates into genomic DNA as an antioxidant defense mechanism. The induced expression of MTH1 in psoriatic skin highlights the altered redox regulation and supports the idea of targeted intervention. Thus, MTH1 inhibition c...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD061700 | Pride
Keratinocytes Th1579 Psoriasis Mass spectrometry Mth1i 
TranscriptomicsRNA-seq of FOXQ1-transfected HCT116 cells to understand the Wnt-dependent and independent FOXQ1 transcriptional output in colorectal cancers.
FOXQ1 is a putative oncogene in several types of carcinomas and, in colorectal cancers, is one of the most highly upregulated genes. FOXQ1 has been previously identified as a candidate Wnt pathway activator in CRC cells. However, it is still unclear how the crosstalk between FOXQ1 and Wnt signalling...
ORGANISM(S): Homo sapiens 
2022-09-23 | E-MTAB-12062 | biostudies-arrayexpress
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