Sort   by:  
 Page size 
ProteomicsFunctional Effects of Extracellular Vesicles Altered by a Per- and Polyfluoroalkyl Substance Mixture: Liver Cell Proteomic Expression Alterations
Extracellular vesicles (EVs) have emerged as key molecules in cellular processes and diseases. The intersection of environmental exposures and EVs has recently gained attention, with EVs being highlighted as biomarkers of exposure, as well as mediators of environmental exposure-induced disease. The ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD050095 | Pride
In vitro Environmental health Extracellular vesicles Proteomics Pfas Liver 
ProteomicsComparison of preservation and storage methods for metaproteomics of intestinal microbiome samples
The aim of this study was to develop a suitable method to preserve fecal samples for metaproteomics analyses when flash-freezing is not an option. Fecal samples were collected from conventional adult C57BL/6 mice and combined into a fecal master mix. The fecal master mix was then split into 48 subsa...
ORGANISM(S): mouse gut metagenome Mus musculus (Mouse) 
2021-11-25 | PXD024115 | Pride
1d-lc  mass spectrometry  ms/ms  metaproteomics  metaproteome  microbiota  microbiome  gut  intestinal  fecal  mouse  storage  preservation. 
ProteomicsProteomics Analysis of Extracellular Vesicles from In Vitro Models of the Human Airway.
Extracellular vesicle (EV)-mediated intercellular communication significantly influences pulmonary cell health and disease outcomes, yet in vitro methods to investigate these pathophysiological mechanisms are limited. We hypothesize that organotypic models of the airway can be leveraged to investiga...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040470 | Pride
Proteome  lc-ms/ms  extracellular vesicles  in vitro models  intercellular communication  cell signaling  human airway  pulmonary disease 
ProteomicsDeep quantitative proteomics of TNBC and SUM149 cell lines treated with USP7 inhibitors
The deubiquitinase USP7 plays an important role in tumorigenesis and is a key regulator of the MDM-p53 pathway. Emerging evidence also supports USP7’s p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers recurrently inactivate p53 and this disease subtype remains ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD059902 | Pride
Tnbc Deubiquitinase Protein degradation Ubiquitin Usp7 
ProteomicsThe role of USP7 in TNBC proteomes
The deubiquitinase USP7 plays an important role in tumorigenesis and is a key regulator of the MDM-p53 pathway. Emerging evidence also supports USP7’s p53-independent roles in proliferation and tumorigenesis. Triple negative breast cancers recurrently inactivate p53 and this disease subtype remains ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD059910 | Pride
Tnbc Deubiquitinase Protein degradation Ubiquitin Usp7 
ProteomicsInvolvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction.
Acute radiation syndrome (ARS) is a severe condition that develops after exposure to high doses of ionizing radiation that features immune suppression and organ failure. Currently, there are no diagnostics to identify the occurrence or severity of radiation exposure. There are also no current treatm...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-06-30 | PXD041837 | Pride
Acute radiation syndrome Mesenchymal stem cells Extracellular vesicles Proteome Ionizing radiation Lc/ms-ms Immune dysfunction 
ProteomicsCharacterization of equine bronchoalveolar lavage fluid extracellular vesicle proteomes across four isolation methods
Growing evidence supports the importance of extracellular vesicle (EV) as mediators of communication in pathological processes, including those underlying respiratory disease. However, establishing methods for isolating and characterizing EVs remains challenging, particularly for respiratory samp...
ORGANISM(S): Equus caballus (Horse) 
2025-05-07 | PXD054702 | Pride
Methods optimization Respiratory Bronchoalveolar lavage Extracellular vesicles Equine Proteome Cell surface markers Lc-ms/ms 
ProteomicsTemporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice.
Introduction Severe injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response effectively. Additionally, a clear biomarker profile to guide...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-21 | PXD062615 | Pride
Protein cargo Extracellular vesicles Macrophages Burn injury Thermal injury Burn injury 
ProteomicsBasal Proteomics of T-cell lymphoma cell cultures
This dataset contains shotgun LC-MS/MS proteomic data from 30 established T- and NK-cell-derived lymphoma cell cultures. These data were collected to quantify baseline protein abundance across in vitro models of peripheral T- and NK-cell lymphomas. In downstream analyses we identified correlations b...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075893 | Pride
T-cells Lymphoma Human Astral Crispr 
ProteomicsUSP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature CMG unloading and replisome disassembly are poorly described. Since...
ORGANISM(S): Homo sapiens (Human) 
2025-05-16 | PXD061463 | Pride
Usp37 Cell cycle Ubiquitin Dna replication Replisome 
Sort   by:  
 Page size