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Endometrial cancer is one of the main gynecological malignancies worldwide, with an estimated 320 000 new cases annually. Several studies highlight ARHGAP35 as a significantly mutated gene in these tumors. It encodes for the protein p190RhoGAP-A (p190A), which is a major regulator of the small GTPas...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067294 | Pride
Entosis is a process that leads to the formation of cell-in-cell structures commonly found in cancers. Here, we identified entosis in hepatocellular carcinoma and the loss of Rnd3 as an efficient inducer of this mechanism. We characterized the different stages and the molecular regulators of entosis...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043640 | Pride
HepG2 cells expressing doxycycline-inducible shRNA were treated by doxycycline for 7 days. Four stable cell lines were used: HepG2 cells expressing a control shRNA; HepG2 cells expressing a shRNA targeting wild-type ß-catenin ; HepG2 cells expressing a shRNA targeting mutated ß-catenin ; HepG2 cell...
ORGANISM(S): Homo sapiens 
Collagen tracks deposited by breast cancer cells contain specific miRNAs which reprogram non-invasive cells into highly pro-metastatic ones by inducing a partial epithelial–mesenchymal transition (EMT) associated with an increase in ECM degradation and cell invasiveness.
ORGANISM(S): Homo sapiens 
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