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ProteomicsMouse WT vs. A20 KO BMDM differential proteomics
A20 is a negative regulator of NF-κB signaling, crucial to control inflammatory responses and ensure tissue homeostasis. A20 is thought to restrict NF-κB activation both by its ubiquitin-editing activity as by non-enzymatic activities. Besides its role in NF-κB signaling, A20 also acts as a protecti...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-15 | PXD008726 | Pride
A20 Lc-msms Bmdm 
ProteomicsExpression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis Expression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis
Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is an important negative regulator of LPS-TLR4 signalling and one report (Wu et al 2016) claimed that sigl...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-09 | PXD008406 | Pride
Mouse bmdm lc-msms 
ProteomicsEpidermal growth factor shedding directs macrophage education in cancer
Macrophages in the tumor microenvironment have a significant impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can either support or constrain tumor growth and metastasis. It is therefore of therapeutic interest to identify the tumor-derived factors that c...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-18 | PXD030740 | Pride
Conditioned medium Lc-msms Mouse Tmt Prm Adam17 Hb-egf 4t1 
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