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ProteomicsProteomics on Nav1.8-positive nociceptors of mouse DRG
Nociceptors play an essential role in both acute pain and chronic pain conditions. In this study, we examined the proteome of mouse dorsal root ganglia and compared NaV1.8Cre+/-; ROSA26-flox-stop-flox-DTA (Diphtheria toxin fragment A) mutant mice (NaV1.8Cre-DTA), in which NaV1.8-positive neurons (ma...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-03 | PXD034447 | Pride
Proteomics Mouse drg Ms Nociception 
TranscriptomicsTranscription profiling of mouse embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time series of neurite outgrowth in vitro
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time series of neurite outgrowth in vitro
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9740 | biostudies-arrayexpress
GenomicsMouse DRG RNA-Seq
Mouse DRG RNA-Seq
PRJNA895420 | ENA
TranscriptomicsWhole transcriptome analysis of FACS purified somatosensory neuron subtypes and whole dorsal root ganglia tissue
The goal of this study was to analyze global gene expression in specific populations of somatosensory neurons in the periphery, including major, non-overlapping populations that include nociceptors, pruriceptors, and prorioceptors. The mammalian somatosensory nervous system encodes the perception of...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-55114 | biostudies-arrayexpress
ProteomicsSCF treatment on murine DRG phospho-proteomics
We employed LC-MS/MS to determine downstream targets of the stem cell factor (SCF)/c-Kit axis in the dorsal root ganglion (DRG). Briefly, we dissected lumbar DRG from male C57BL/6 mice and treated ex vivo with vehicle or SCF for 10 min or 1 hour. DRG were then subjected to LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2026-04-28 | PXD076785 | Pride
Lc-ms/ms Pain Drg Scf 
TranscriptomicsComparative microarray analysis of NaV1.8-expressing DRG neurons and cold-sensitive non-NaV1.8-expressing DRG neurons
The vast majority of cold sensitive DRG neurons from mice do not express the voltage-gated sodium channel NaV1.8. Therefore, we aimed to compare the molecular profiles of NaV1.8 and non-NaV1.8-expressing neurons using microarray analysis. Fluorescent activated cell sorting was performed at 4 degrees...
ORGANISM(S): Mus musculus musculus 
2019-07-01 | E-MTAB-7070 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse neurite outgrowth and regeneration
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9738 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling in dorsal root ganglion after sciatic nerve injury
Changes in microRNA (miRNA) expression in the mouse L4 and L5 dorsal root ganglion following unilateral sciatic nerve transection. The timepoint of 7 days post-axotomy was chosen to capture miRNA expression profiles at a time when the injured neurons were beginning to regenerate. Two condition exper...
ORGANISM(S): Mus musculus 
2011-05-06 | E-GEOD-29096 | biostudies-arrayexpress
TranscriptomicsExpression data of three sets of cells: (1) Schwann cells and macrophages from 1m-old WT DRG, (2) Schwann cells (Nf1-/-) and macrophages (Nf1+/+) from 1m-old neurofibroma, (3) Schwann cells (Nf1-/-) and macrophages (Nf1+/+) from 7m-old neurofibroma
Schwann cells and macrophages were dissociated from normal DRGs and 1- and 7-month-old neurofibroma. Schwann cells from neurofibroma have Nf1-/- phenotypes. All macrophages have Nf1+/+ phenotypes. We used microarrays (Affymetrix MoGene 2.0 ST GeneChip) to detect transcriptomal changes between 7-mont...
ORGANISM(S): Mus musculus 
2017-05-01 | E-GEOD-78901 | biostudies-arrayexpress
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