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ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS pulse labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033702 | Pride
Pulse labeling Hdx-ms Mpro Sars-cov-2 Polyprotein 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS continuous labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033698 | Pride
Hdx-ms Mpro Sars-cov-2 Polyprotein Continuous labeling 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (XL-MS)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033748 | Pride
Nsp7-8 Xl-ms Nsp7-11 Mpro Sars-cov-2 Polyprotein 
ProteomicsCharacterization of MPro substrate specificity by HTPS
Characterization of MPro substrate specificity by HTPS using temporal resolution (5min, 30min, 4hrs, 24hrs)
ORGANISM(S): Homo sapiens (Human) 
2025-07-02 | PXD044733 | Pride
Degradomics Htps 
ProteomicsStatistical crystallography reveals an allosteric network in SARS-CoV-2 Mpro
To interpret and transmit biological signals, proteins use correlated motions. Experimental determination of these dynamics and the structural distributions they generate remains a key challenge. Here, using 1146 crystal structures of the main protease (Mpro) from SARS-CoV-2, we were able to infer a...
ORGANISM(S): Escherichia coli 
2026-04-14 | PXD076496 | Pride
Enzymology Sars-cov-2 Crystallography 
TranscriptomicsGlobal murine neutrophil response to highly and less virulent influenza A (H3N2) virus infections at 3 and 9 h post-infection
Array analysis of total RNA obtained from MPRO neutrophils collected at 3 and 9 h post-infection with highly and less virulent influenza A (H3N2) viruses. Viruses (designated as LVI, HVI and MPI) were derived from influenza strain virus A/Aichi/2/68 (Aichi68). LVI is Aichi68 propagated in eggs, HVI ...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-55995 | biostudies-arrayexpress
ProteomicsA yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations
The SARS-CoV-2 main protease (Mpro) is a major therapeutic target. The Mpro inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As Mpro inhibitor use increases, drug resistant mutations will likely emerge. We have established a non-pathogenic ...
ORGANISM(S): Saccharomyces cerevisiae Caenorhabditis elegans 
2023-08-08 | PXD036325 | Pride
Covid-19 
TranscriptomicsThe SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
COVID-19 can damage cerebral small vessels and cause neurological symptoms. However, the vascular pathology and the potential mechanisms are unclear. In brains of SARS-CoV-2-infected patients and animal models, we found an increased number of empty basement membrane tubes, so-called string vessels r...
ORGANISM(S): Mus musculus 
2021-07-31 | GSE180984 | GEO
ProteomicsIP-MS raw data of proteins precipitated by Mpro-Flag and the phosphorylation site of Mpro in 293T-Mpro-Flag cells
The main protease (Mpro, also known as 3CLpro) of SARS-CoV-2 plays a pivotal role in the viral life cycle by mediating the cleavage of viral polyproteins. Understanding the regulatory mechanisms of Mpro, including its protein-protein interactions (PPIs) and post-translational modifications (PTMs), i...
ORGANISM(S): Homo Sapiens 
2026-03-02 | PXD075077 |
GenomicsThe SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
PRJNA750311 | ENA
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