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ProteomicsThe kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses
In coronavirus (CoV) infection, polyproteins (pp1a/pp1ab) are processed into non-structural proteins (nsps), which largely form the replication/transcription complex (RTC). The polyprotein processing and complex formation is critical and offers potential therapeutic targets. However, the interplay o...
ORGANISM(S): Escherichia coli 
2025-07-08 | PXD049009 | Pride
Mass spectrometry Sars-cov-2 Kinetics Native ms Rate constants Complexation 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (XL-MS)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033748 | Pride
Nsp7-8 Xl-ms Nsp7-11 Mpro Sars-cov-2 Polyprotein 
UnknownThe kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses.
Not available
S-EPMC12420816 | biostudies-literature
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS pulse labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033702 | Pride
Pulse labeling Hdx-ms Mpro Sars-cov-2 Polyprotein 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS continuous labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033698 | Pride
Hdx-ms Mpro Sars-cov-2 Polyprotein Continuous labeling 
UnknownPublisher Correction: The kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses.
Not available
S-EPMC12511612 | biostudies-literature
UnknownBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro.
Not available
S-EPMC9733933 | biostudies-literature
UnknownSARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites.
Not available
S-EPMC8396565 | biostudies-literature
UnknownMutational Frequencies of SARS-CoV-2 Genome during the Beginning Months of the Outbreak in USA.
Not available
S-EPMC7400123 | biostudies-literature
UnknownExpression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected Cells.
Not available
S-EPMC9431475 | biostudies-literature
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