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ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS pulse labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033702 | Pride
Pulse labeling Hdx-ms Mpro Sars-cov-2 Polyprotein 
GenomicsSelective polyprotein processing determines norovirus sensitivity to Trim7
Selective polyprotein processing determines norovirus sensitivity to Trim7
PRJEB47213 | ENA
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS continuous labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033698 | Pride
Hdx-ms Mpro Sars-cov-2 Polyprotein Continuous labeling 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (XL-MS)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033748 | Pride
Nsp7-8 Xl-ms Nsp7-11 Mpro Sars-cov-2 Polyprotein 
ProteomicsThe kinetics of nsp7-11 polyprotein processing and impact on complexation with nsp16 among human coronaviruses
In coronavirus (CoV) infection, polyproteins (pp1a/pp1ab) are processed into non-structural proteins (nsps), which largely form the replication/transcription complex (RTC). The polyprotein processing and complex formation is critical and offers potential therapeutic targets. However, the interplay o...
ORGANISM(S): Escherichia coli 
2025-07-08 | PXD049009 | Pride
Mass spectrometry Sars-cov-2 Kinetics Native ms Rate constants Complexation 
ProteomicsMapping viral protease-mediated processing of astrovirus nonstructural polyprotein C4PR_LIV
Many viruses with compact RNA genomes use a replication strategy involving the translation and proteolytic processing of a polyprotein. Astroviruses include a range of human and animal species and can infect cells of intestinal and neuronal origin. These viruses have positive-sense RNA genomes and t...
ORGANISM(S): Human astrovirus 1 Homo sapiens (Human) Human astrovirus MLB2 
2026-06-07 | PXD058484 | Pride
Tmt-hunter N-terminomics Astrovirus 
GenomicsTime-dependent processing of dengue virus polyprotein yields multiple capsid forms that disrupt cellular homeostasis
Time-dependent processing of dengue virus polyprotein yields multiple capsid forms that disrupt cellular homeostasis
PRJNA1471001 | ENA
GenomicsSindbis virus
Sindbis virus structural polyprotein -1 PRF deep mutational scan
PRJNA720960 | ENA
UnknownSelective Polyprotein Processing Determines Norovirus Sensitivity to Trim7.
Not available
S-EPMC9472627 | biostudies-literature
TranscriptomicsTime-dependent processing of dengue virus polyprotein yields multiple capsid forms that disrupt cellular homeostasis
Dengue virus infections spread to new geographical regions every year, cause significant morbidity and mortality, yet the progress in drug/vaccine development is limited due to an incomplete understanding of its life cycle. While a few of the proteins coded by this virus exist in multiple forms, the...
ORGANISM(S): Homo sapiens 
2026-06-08 | GSE333382 | GEO
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