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TranscriptomicsVTA neurons show an adaptive transcriptional response to MPTP which differs from SN neurons
Implications for neuroprotection in Parkinson's disease Parkinson’s disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (DA) neurons. In humans, DA neurons of the substantia nigra (SN) and their projections to the striatum sh...
ORGANISM(S): Mus musculus 
2009-12-31 | E-GEOD-17542 | biostudies-arrayexpress
ProteomicsBeta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
Previous studies have demonstrated an importance of alpha-synuclein as a modulator of various mechanisms implicated in chemical neurotransmission but information about other two synuclein family members’ involvement in molecular processes taking place in presynaptic terminals is limited. Here we dem...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027786 | Pride
Dopamine Synapse Mptp toxicity Synuclein Transgenic mice Dopaminergic neurons Parkinson’s disease Vesicles Neurodegenerative disease Neurotransmitter vesicular uptake 
ProteomicsBeta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
Previous studies demonstrated that dopaminergic neurons in the substantia nigra pars compacta (SNpc) of mice with null mutations for genes encoding a-synuclein and/or y-synuclein are resistant to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity. An original straightforward interpretation...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD027667 | Pride
Dopamine Lc-msms Synapse Mptp toxicity Transgenic mice Dopaminergic neurons Mouse Parkinson’s disease Synuclein Vesicles Neurodegenerative disease Neurotransmitter vesicular uptake 
ProteomicsReactive Metabolite-induced Protein Glutathionylation Mechanistically Accounts for Acetaminophen Hepatotoxicity
Although covalent protein binding is established as the pivotal event underpinning acetaminophen (APAP) toxicity, its mechanistic details remain unclear. In this study, we demonstrated that APAP induces widespread protein glutathionylation in a time-, dose- and bioactivation-dependent manner in Hepa...
ORGANISM(S): Homo Sapiens (human) 
2018-09-20 | PXD009986 | JPOST Repository
UnknownBotanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTP/MPP+-Induced Toxicity via Progesterone Receptor Signaling.
Not available
S-EPMC7586160 | biostudies-literature
UnknownRET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.
Not available
S-EPMC2148420 | biostudies-literature
UnknownDecreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice.
Not available
S-EPMC4294392 | biostudies-literature
TranscriptomicsVTA neurons show an adaptive transcriptional response to MPTP which differs from SN neurons
Implications for neuroprotection in Parkinson's disease Parkinson’s disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (DA) neurons. In humans, DA neurons of the substantia nigra (SN) and their projections to the striatum show...
ORGANISM(S): Mus musculus 
2010-01-01 | GSE17542 | GEO
UnknownCerebroventricular Injection of Pgk1 Attenuates MPTP-Induced Neuronal Toxicity in Dopaminergic Cells in Zebrafish Brain in a Glycolysis-Independent Manner.
Not available
S-EPMC9025024 | biostudies-literature
UnknownMicroglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease.
Not available
S-EPMC10324349 | biostudies-literature
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