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UnknownAn enhanced protein crosslink identification strategy using CID-cleavable chemical crosslinkers and LC/MS(n) analysis.
Not available
S-EPMC3426502 | biostudies-literature
ProteomicsIdentification of MS-Cleavable and Non-Cleavable Chemically Crosslinked Peptides with MetaMorpheus
The present work describes a novel search program for the detection of both MS-cleavable and non-cleavable crosslinked peptides and it is the first software program reported with both capacities. The search strategy has been implemented in the computer program MetaMorpheus, which has a user-friendly...
ORGANISM(S): Escherichia coli 
2018-07-16 | PXD009000 | Pride
Proteomics Ms-cleavable chemical crosslink Protein-protein interactions Ion index 
UnknownIncreased sensitivity with automated validation of XL-MS cleavable peptide crosslinks.
Not available
S-EPMC6394394 | biostudies-literature
ProteomicsXLinkProphet ReACT XL-MS - Increased sensitivity with automated validation of XL-MS cleavable peptide crosslinks
Control Data Crosslink ReACT Results Searched with Comet
ORGANISM(S): Bos taurus (Bovine) Saccharomyces cerevisiae (Baker's yeast) Equus caballus (Horse) 
2019-07-12 | PXD009001 | Pride
Crosslink standard data react results 
ProteomicsComparison of MS Annika 3.0 against other crosslink search engines
The field of crosslinking mass spectrometry has seen substantial advancements over the past decades, enabling the structural analysis of proteins and protein-complexes and serving as a powerful tool in protein-protein interaction studies. However, data analysis of large non-cleavable crosslink studi...
ORGANISM(S): Streptoccous pyogenes Escherichia coli 
2024-12-19 | PXD055512 | Pride
Non-cleavable Dss Adh Crosslinker Crosslinking 
Proteomics4-ONE as a Chemoselective Biological Glue for Site-Resolved Protein Crosslinking and Proteomic Profiling
Protein crosslinking governs structure, stability, and interaction networks in biology, yet current chemical crosslinkers lack selectivity, produce heterogeneous products, and require pre-installed cleavable handles for analysis. Here, we report a conceptually distinct strategy that harnesses the in...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD070252 | Pride
ProteomicsProteome-Wide Photo-Crosslinking Enables Residue-Level Visualization of Protein Interaction Networks in vivo
Crosslinking mass spectrometry (XL-MS) is emerging as a unique method at the crossroads of structural and cellular biology, uniquely capable of identifying protein-protein interactions with residue-level resolution and on the proteome-wide scale. With the development of crosslinkers that can form li...
ORGANISM(S): Escherichia coli 
2023-12-07 | PXD036884 | Pride
Heterobifunctional crosslinker Escherichia coli Xl-ms Diazirine Cleavable crosslinker Photo-crosslinking Proteome-wide Nhs-carbamate 
ProteomicsA high-efficiency Azide-A-DSBSO cross-linking-MS protocol for identifying thousands of in vivo protein interactions in single day
Enrichable and mass spectrometry (MS)-cleavable crosslinkers have gained popularity in crosslinking-MS (XL-MS) in the past decade. The azide-tagged, acid-cleavable disuccinimidyl bis-sulfoxide (DSBSO) crosslinker offers both these advantages, enabling deep XL-MS interactomics studies in intact cells...
ORGANISM(S): Homo sapiens (Human) Bacillus subtilis 
2025-11-27 | PXD065905 | Pride
High-thoughput Cross-linking mass spectrometry Dsbso 
UnknownExpanding the Crosslinking Mass Spectrometry Toolbox With Vinyl Sulfone Crosslinkers.
Not available
S-EPMC12682122 | biostudies-literature
ProteomicsIn Situ Structural Restraints from Crosslinking Mass Spectrometry in Human Mitochondria
The field of structural biology is increasingly focusing on studying proteins in situ, i.e. in a larger biological context. Crosslinking mass spectrometry is contributing to this effort, typically through the use of MS-cleavable crosslinkers. Here, we apply the popular non-cleavable crosslinker disu...
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD014675 | Pride
Crosslinking mass spectrometry Human mitochondria In situ large-scale structural biology Non-cleavable dss crosslinker Comparative modelling 
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