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ProteomicsProteomics Analysis of Human Mesenchymal Stromal/Stem Cell Sarcomagenesis Model Identifies ALDH1A3 and CD99 as Potential Targets in the Transformation Process
Mesenchymal stromal/stem cells (MSC) may represent the cell-of-origin for sarcoma development. A collection of human MSCs sequentially mutated with an increasing number of oncogenic hits served to recreate a step-wise process of sarcomagenesis. To identify potential protein targets of interest in th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069892 | Pride
Msc-sarcoma model Sarcomagenesis Cd99 Proteomics (lc-ms/ms) Aldh1a3 
TranscriptomicsExpression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation
Although different sarcomas have been modeled in mice upon expression of fusion oncogenes in MSCs, sarcomagenesis has not been successfully modeled in human MSCs (hMSCs). We report that FUS-CHOP, a hallmark fusion gene in mixoid liposarcoma (MLS), has an instructive role in lineage commitment, and i...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48030 | biostudies-arrayexpress
UnknownA genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.
Not available
S-EPMC4418175 | biostudies-literature
TranscriptomicsEWS-FLI1 reactivates a neural crest stem cell program in human neural crest-derived mesenchymal stem cells
Ewing sarcoma family of tumors (ESFT) are aggressive bone and soft tissue tumors of unknown cellular origin. Most ESFT express EWS-FLI1, a chimeric protein which functions as a growth-promoting oncogene in ESFT but is toxic to most normal cells. A major difficulty in understanding EWS-FLI1 function ...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-21511 | biostudies-arrayexpress
TranscriptomicsRNAseq of human Ewing, MSC, fibroblast cell lines - A side population of Ewing cells exhibits stem cell properties
Ewings Sarcoma (ES) belongs to the group of bone cancers defined by the existence of a certain EWS-ETS fusion gene. In this study we use the model cell line CADO-ES1 (EWSR1-ERG fusion gene) to characterize the tumor biology of a versatile ES side-population (SP). We aim to compare SP- and non-SP-cel...
ORGANISM(S): Homo sapiens 
2017-10-31 | E-MTAB-6067 | biostudies-arrayexpress
ProteomicsProteomic charaterization of GPX1 depletion in sarcoma models
The sarcomagenic process initiates upon the tumoral transformation of mesenchymal stromal/stem cell (MSCs) or MSC-derived cell types. Experimental evidence also supports that sarcoma evolution is in part driven by the emergence of subpopulations of cancer stem cells (CSCs) after the accumulation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD052595 | Pride
Human Sarcoma Cscs Gpx1 
ProteomicsGPX1 expression promotes stemness and aggressiveness in sarcomas
The sarcomagenic process initiates upon the tumoral transformation of mesenchymal stromal/stem cell (MSCs) or MSC-derived cell types. Experimental evidence also supports that sarcoma evolution is in part driven by the emergence of subpopulations of cancer stem cells (CSCs) after the accumulation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD053403 | Pride
Myxoid liposarcoma Proteomics Gpx1 Cancer stem cells Sarcoma Oxidative stress 
TranscriptomicsMesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits [bulk RNA-seq]
Soft tissue sarcomas (STSs) are a heterogeneous group of tumors that originate from mesenchymal cells. p53 is frequently mutated in human STS. In this study, we found that the loss of p53 in mesenchymal stem cells (MSCs) mainly causes adult undifferentiated soft tissue sarcoma (USTS). MSCs lacking p...
ORGANISM(S): Mus musculus 
2023-03-08 | GSE226843 | GEO
TranscriptomicsMesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits [scRNA-seq]
Soft tissue sarcomas (STSs) are a heterogeneous group of tumors that originate from mesenchymal cells. p53 is frequently mutated in human STS. In this study, we found that the loss of p53 in mesenchymal stem cells (MSCs) mainly causes adult undifferentiated soft tissue sarcoma (USTS). MSCs lacking p...
ORGANISM(S): Mus musculus 
2023-03-21 | GSE226845 | GEO
TranscriptomicsBioinformatics-based selection of a model cell type for in vitro biomaterial testing
Biomaterial properties can be tailored for specific applications via systematic and high-throughput screening of biomaterial–cell interactions. However, progress in material development is often hampered by the lack of adequate in vitro testing methods, frequently due to incomplete understanding of ...
ORGANISM(S): Homo sapiens 
2018-08-12 | E-MTAB-7057 | biostudies-arrayexpress
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