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GenomicsDNA-seq of mitochondrial DNA from mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mitochondrial DNA mutation load. Oxidative stress has been suggested to induce mutations in mtDNA. To verify this, we extracted and sequenced (Illu...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6533 | biostudies-arrayexpress
GenomicsDNA-seq of mitochondrial DNA from liver of OGG1 and MUTYH deficient mice that have been bred for five consecutive generations
Studying whether removal of base-excision repair from mitochondria will result into increase in mitochondrial DNA (mtDNA) mutation load. The endogenous genes of OGG1 and MUTYH DNA glycosylases were modified to lack the genomic region encoding for the predicted mitochondrial targeting sequence. The m...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6532 | biostudies-arrayexpress
TranscriptomicsReduced protein kinase A signaling can diminish the nuclear transcriptional response to mtDNA damage in Saccharomyces cerevisiae
Damage to the mitochondrial genome (mtDNA) severely affects the cell and causes disease. Mutations to mtDNA also accumulate throughout the lifespan of many organisms and may be a proximal cause of aging. There is no effective treatment for ailments caused by mtDNA mutation. Since mitochondrial funct...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-07 | E-GEOD-71252 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mutations in mitochondrial RNA (mtRNA). Oxidative stress has been suggested to induce mutations in mtDNA and as DNA is used as a template in transc...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6534 | biostudies-arrayexpress
TranscriptomicsDeletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae
Mitochondrial biogenesis is regulated by signaling pathways sensitive to extracellular conditions and to the internal environment of the cell. We found that deletion of protein phosphatase 2A (PP2A) or of protein phosphatase 6 (PP6) diminishes the nuclear transcriptional response associated with mtD...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-23 | E-GEOD-52242 | biostudies-arrayexpress
ProteomicsMitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
Integrity of mitochondrial DNA (mtDNA), encoding several subunits of the respiratory chain, is essential to maintain mitochondrial fitness. Mitochondria, as a central hub for metabolism, are affected in a wide variety of human diseases but also during normal ageing, where mtDNA integrity is compromi...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-07 | PXD023939 | Pride
Mitophagy Twinkle Autophagy Mitochondrial nucleoid Mtdna 
ProteomicsProximity labelling of mitochondria and endosomes upon mtDNA replication stress.
This project aims to identify novel regulators of mtDNA turnover, for what we used TurboID. For specific detection of the mitochondria-endosome proteome, we fused the N-terminal part of Turbo ID to RAB5C (TurboID aa1-aa72; RAB5C-SplitTurboNt-V5) and, the C-terminal part to SAMM50 (TurboID aa73–aa246...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD049081 | Pride
Mtdna Mitochondria Turboid 
ProteomicsImpaired mitochondrial DNA maintenance in NAFLD: associations between mtDNA copy number, mtDNA damage and BER factors
Non-alcoholic fatty liver disease (NAFLD) is characterized by mitochondrial dysfunction and oxidative stress, potentially compromising mitochondrial DNA (mtDNA) integrity. The contribution of base excision repair (BER) to mtDNA maintenance in NAFLD remains poorly understood. Here, we analyzed mtDNA ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD075974 | Pride
Prm Leukocytes Mitochondria Evosep one Orbitrap astral Surequant 
TranscriptomicsMitochondrial DNA mutations induce supression of nuclear encoded mitochondrial Genes in skeletal muscle
To identify and analyze mtDNA mutation-responsive genes, a comparison of gastrocnemius muscle tissues from WT (control) and D257A mice was conducted. We examined changes in gene expression in the muscle associated with mtDNA mutations. 1) Types of experiments: a) Effect of mitochondrial DNA (mtDNA) ...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21189 | biostudies-arrayexpress
GenomicsHybrid lizards with introgressed mtDNA show resistance to DNA damage from Reactive Oxygen Species
Hybrid lizards with introgressed mtDNA show resistance to DNA damage from Reactive Oxygen Species
PRJNA1077356 | ENA
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