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TranscriptomicsTranscription profiling of human induced pluripotent stem cells signature and memory retention
Transient expression of two factors, or from Oct4 alone, resulted in efficient generation of human iPSCs. The reprogramming strategy described revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and...
ORGANISM(S): Homo sapiens 
2009-12-19 | E-GEOD-18618 | biostudies-arrayexpress
ProteomicsProteomic dataset of MECP2-deficient and wild-type human brain organoids under spaceflight and ground conditions
This dataset presents deep proteomic profiles of human brain organoids cultured aboard the International Space Station (ISS) and on Earth. We analyzed MECP2-deficient (Q83X) and isogenic wild-type control (WT83) organoids exposed to spaceflight and ground conditions for 30 days. Using LC-MS/MS on an...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD069807 | Pride
Astrocytes Proteomics Brain organoids L1 retrotransposition Mecp2 Microgravity Retrotransposons Neurodegeneration Senescence 
TranscriptomicsModeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-62632 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood
Mesenchymal stem cells (MSC) are multipotent cells which can be obtained from several adult and fetal tissues including human umbilical cord units. We have recently shown that umbilical cord tissue (UC) is richer in MSC than umbilical cord blood (UCB) but their origin and characteristics in blood a...
ORGANISM(S): Homo sapiens 
2009-09-18 | E-GEOD-18134 | biostudies-arrayexpress
UnknownTranscriptional perturbation of LINE-1 elements reveals their cis-regulatory potential
Not available
S-SCDT-10_1038-S44319-026-00854-W | biostudies-other
TranscriptomicsL1 retrotransposition in neurons is mediated by MeCP2
L1 retrotransposons are active elements in the genome, capable of mobilization in neuronal progenitor cells. Previously, we showed that chromatin remodeling during neuronal differentiation allows for a transient stimulation of L1 transcription. The activity of L1 retrotransposons during brain develo...
ORGANISM(S): Homo sapiens 
2010-11-11 | E-GEOD-21037 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neural progenitor cells and their differentiation into neurons and astrocytes
Experiment comparing Low-density, CCg derived, progenitors (LDP) with high-density progenitors (HDP), and neurons (LDN) and astrocytes (LDA) derived from the LDP condition
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2499 | biostudies-arrayexpress
UnknownConvergent Activation of the Integrated Stress Response and ER-Mitochondria Uncoupling in VAPB-Associated ALS
Not available
S-SCDT-10_1038-S44321-025-00279-3 | biostudies-other
TranscriptomicsA quantitative framework to evaluate modeling of cortical development by neural stem cells
In vitro neural stem cell models are widely used to model a wide range of neuropsychiatric conditions. However, how well such models correspond to in vivo brain has not been evaluated in an unbiased, comprehensive manner. We used transcriptomic analyses to compare in vitro systems to developing huma...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-57595 | biostudies-arrayexpress
UnknownChemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics
Not available
S-SCDT-EMBOJ-2018-99763 | biostudies-other
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