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UnknownThe FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.
Not available
S-EPMC5266791 | biostudies-literature
ProteomicsDeciphering the role of PGRMC2 in the human endometrium during the menstrual cycle and in vitro decidualization using an in vitro approach
Understanding how P4 signaling occurs in endometrial cells is important to guide the development of more effective therapeutic approaches to the numerous reproductive diseases caused by disrupted P4 signaling, resulting in subfertility or infertility (Bunch et al., 2013; Kim et al., 2013; Zhang and ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048494 | Pride
Proteomics Pgrmc2 Menstrual cycle Progesterone receptor Progesterone Decidualization Human endometrium Endometrial stromal cells Transcriptomics 
ProteomicsPSMF1 variants cause a phenotypic spectrum from early-onset Parkinson’s disease to perinatal lethality and disrupt mitochondrial pathways
Dissecting biopathways unveiled by Mendelian gene discovery has provided critical insights into the pathogenesis of Parkinson’s disease (PD) and neurodegeneration, hence catalyzing the identification of potential biomarkers and therapeutic targets. Here, we identify PSMF1 as a new gene implicated in...
ORGANISM(S): Homo sapiens (Human) 
2026-03-03 | PXD053147 | Pride
Parkinson's disease Psmf1 Neurodegeneration 
ProteomicsNovel non-canonical role of STAT1 in Natural Killer cell cytotoxicity
STAT1 is an important regulator of NK cell maturation and cytotoxicity. Although the consequences of Stat1-deficiency have been described in detail the underlying molecular functions of STAT1 in NK cells are only partially understood. Here we describe a novel non-canonical role of STAT1 that was unm...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-07 | PXD002206 | Pride
Immunological synapse Vesicle F-actin Proteome Interactome 
UnknownProperties of single voltage-gated proton channels in human eosinophils estimated by noise analysis and by direct measurement.
Not available
S-EPMC2217352 | biostudies-literature
ProteomicsA novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. It has been proposed as an actionable target to alleviate the loss of function of the mitophagy pathway governed by the Parkinson’s Disease associated genes PINK1 and PRKN. We present the cha...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD018640 | Pride
Ubiquitylome Mitophagy Lc-ms Deubiquitylase Usp30 Parkinson’s disease Dub inhibitor Ubiquitin 
UnknownAnnexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions.
Not available
S-EPMC8755831 | biostudies-literature
TranscriptomicsGene expression changes between primary mesothelioma tumour cells and commercially available cell lines, compared to normal primary mesothelial cells
Malignant mesothelioma (MM) is an aggressive, fatal tumour strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and robust tool widely used...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-6351 | biostudies-arrayexpress
UnknownAssociation of clinical severity with FANCB variant type in Fanconi anemia.
Not available
S-EPMC7193183 | biostudies-literature
UnknownBacterial formate hydrogenlyase complex.
Not available
S-EPMC4183296 | biostudies-literature
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