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ProteomicsInhibition of Acyl-CoA Synthetase Long Chain (ACSL) Isozymes Decreases Multiple Myeloma Cell Proliferation, Mitochondrial Function and Affects Key Survival Pathways
Multiple myeloma (MM) is an incurable cancer of plasma cells that will cause ~12,590 deaths in the USA in 2023. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression but the underlying mechanisms remain unknown. The acyl-CoA synthetase long-chain family member...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD049304 | Pride
Triacsin c Acsl Multiple myeloma Mm.1s Acyl-coa synthetase long chain Fatty acid metabolism 
ProteomicsQuantitative Proteome Responses to Oncolytic Reovirus in GM-CSF and M-CSF-Differentiated Bone Marrow-Derived Cells
To explore reovirus-macrophage interactions, we performed tandem mass tag (TMT)-based quantitative temporal proteomics on mouse bone marrow-derived macrophages (BMMs) generated with 2 cytokines, M-CSF and GM-CSF, representing anti- and pro-inflammatory macrophages, respectively. We quantified 6,863 ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-07 | PXD015203 | Pride
Reovirus Cell differentiation Macrophages Oncolytic viruses Antigen presentation/processing Viral defense Quantitative proteomics Anti-viral immune response 
ProteomicsQuantitative Temporal in vivo Proteomics (QTiPs) deciphers the transition of inflammatory CD11b+,Ly6G-,Ly6Chigh myeloid cells into M2-like macrophages
Phenotypic transition of myeloid cells into distinct lineages in vivo is important in pathogen response. To monitor immune cell phenotype transitions in vivo, we developed a quantitative temporal in vivo proteomics (QTiPs) platform, performing multiplexed (10-plex) tandem-mass-tag (TMT)-based mass s...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD005064 | Pride
Proteomics Myeloid cells M2-like macrophages Infection 
UnknownSelective effects of isoflurane on cortico-cortical feedback afferent responses in murine non-primary neocortex.
Not available
S-EPMC6871270 | biostudies-literature
UnknownA precise metallicity and carbon-to-oxygen ratio for a warm giant exoplanet from its panchromatic JWST emission spectrum.
Not available
S-EPMC12501160 | biostudies-literature
ProteomicsRIPK3 is released into Extracellular Vesicles during Necroptosis through a Rab27 independent mechanism
Extracellular vesicles (EVs) are important mechanisms used by cells to release biomolecules. A common necroptosis effector— mixed lineage kinase like (MLKL)--- was recently found to participate in the biogenesis of small and large EVs independent of its function in necroptosis. The objective of the ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-14 | PXD031224 | Pride
Lysosomal exocytosis Ripk3 Sevs Mlkl Necroptosis Proteomics 
UnknownIntraocular Pressure-Related Events After Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Due to Central Retinal Vein Occlusion or Hemiretinal Vein Occlusion: SCORE2 Report 16 on a Secondary Analysis of a Randomized Clinical Trial.
Not available
S-EPMC8554687 | biostudies-literature
UnknownComparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury.
Not available
S-EPMC8914575 | biostudies-literature
UnknownHealth data use, stewardship, and governance: ongoing gaps and challenges: a report from AMIA's 2012 Health Policy Meeting.
Not available
S-EPMC3932468 | biostudies-literature
ProteomicsAfter virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is know...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-30 | PXD039614 | Pride
T cell Mouse Reovirus 
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