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MetabolomicsEndothelial Sirtuin1 Suppresses Whole-body Insulin Sensitivity by Modulating the Secretome
Not available
ORGANISM(S): Mus musculus 
ST002204 | MetabolomicsWorkbench
ProteomicsMarked increased production of acute phase reactants by skeletal muscle during cancer cachexia
Background Loss of skeletal muscle mass in cancer cachexia is recognized as an independent predictor of mortality. Mechanisms involved in this wasting process and parameters for early diagnosis are not yet clearly defined. As skeletal muscle is considered as a secretory organ, the aim of this prese...
ORGANISM(S): Mus Musculus 
2021-01-24 | PXD019433 | panorama
TranscriptomicsAnnotating the secretome of mature primary human muscle cells
The Skeletal muscle is a metabolic active tissue that secretes various proteins. These so called myokines act auto-, para- and endocrine affecting muscle physiology and exert systemic effects on other tissues and organs. Myokines are also described to play a crucial role in the pathophysiology of me...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45473 | biostudies-arrayexpress
ProteomicsMouse Smooth muscle cell secretome with Anti-miR / pre-miR treatment
Overexpression and inhibition of miR-29 (pre-miR and anti-miR to miR-29b) in murine aortic smooth muscle cells, analysis of their secretome (conditioned media after serum starvation), n=3 for all four groups (pre-miR control, pre-miR-29b, anti-miR control, anti-miR-29b).
ORGANISM(S): Mus musculus (Mouse) 
2016-05-06 | PXD003938 | Pride
Mouse Smooth muscle cell Mir-29 
ProteomicsInsulin and 5-aminoimidazole-4-carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
Skeletal muscle is a major contributor to whole-body glucose homeostasis and is an important endocrine organ. To date, few studies have undertaken the large-scale identification of skeletal muscle-derived secreted proteins (myokines), particularly in response to stimuli that activate pathways govern...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD025687 | Pride
Muscle Metabolism Insulin Secretome Aicar Lcms 
TranscriptomicsCytokines dominate the secretome of primary human myotubes in an in vitro exercise model
Muscle contraction during exercise is the major stimulus for the release of peptides and proteins (myokines) that are supposed to take part in the benefical adaptation to exercise. We hypothesize that application of an in vitro exercise stimulus as electric pulse stimulation (EPS) to human myotubes ...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-44051 | biostudies-arrayexpress
ProteomicsMining the secretome of C2C12 muscle cells
Secretome analysis faces several challenges, including detection of low abundant proteins and the discrimination of bona fide secreted proteins from false-positive identifications stemming from cell leakage or serum. Here, we developed a two-step secretomics approach and applied it for the analysis ...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-24 | PXD007527 | Pride
Skeletal muscle cells Esi-lc-ms/ms Lspfp Proteolytic processing Secretome Plexin-b2 
TranscriptomicsGene expression profiling in porcine chronic myocardial ischemia treated with intramyocardial injections of secretome
Closed-chest reperfused MI was induced in pigs by 90-min occlusion, followed by reperfusion of the mid LAD (day 0) and by cardiac MRI with late enhancement (LE) at day 3. At day 30 the animals received either porcine APOSEC (n=8) or placebo medium (n=8) in a randomized manner, injected into the bord...
ORGANISM(S): Sus scrofa 
2013-12-31 | E-GEOD-47397 | biostudies-arrayexpress
ProteomicsEMILIN1 emerges as a SETDB1-dependent modulator of the secretome in Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) is an incurable muscle-wasting disorder characterized by chronic membrane damage, inflammation, and progressive fibrosis. Fibrosis in DMD is driven by sustained TGF signaling, which promotes extracellular matrix (ECM) accumulation. We previously showed that SETDB1 s...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD074360 | Pride
Tgfbeta Muscle fibrosis Human muscular dystrophy Muscle secretome Duchenne muscular dystrophy 
GenomicsStem cell secretome-treatment improves whole-body metabolism, reduces adiposity and promotes skeletal muscle function in aged mice
Stem cell secretome-treatment improves whole-body metabolism, reduces adiposity and promotes skeletal muscle function in aged mice
PRJNA1011995 | ENA
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