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MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
ProteomicsDysferlin stabilizes membrane nanodomains of cardiomyocytes after myocardial infarction - spatial tissue proteomics
BACKGROUND: Despite significant advances in acute care medicine, myocardial infarction (MI) remains a predominant cause of premature death and heart failure. In the infarct border zone, cardiomyocytes are exposed to high biomechanical stress that impairs the integrity of the sarcolemmal membrane. He...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD060267 | Pride
Myocardial ischemia Proteomics Cardiomyocytes Connexin-43 Dysferlin Intracellular membranes Myocardial infarction 
ProteomicsMyocardial Injury Caused by Chronic Alcohol Exposure——A Pilot Study Based on Proteomic
Chronic alcohol exposure can cause myocardial degenerative diseases, manifested as cardiac insufficiency, arrhythmia, etc. These are defined as alcoholic cardiomyopathy (ACM). Alcohol-mediated myocardial injury has previously been studied through metabolomics, and it has been proved to be involved i...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD032949 | Pride
Alcoholic cardiomyopathy  proteomics  differentially expressed proteins  kegg pathway  myocardial injury 
ProteomicsHuman HFpEF Myocardial Proteomics
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD045677 | Pride
Proteomics Myocardium Obesity Molecular medicine Heart disease Human 
ProteomicsShort-term blockade of pro-inflammatory alarmin S100A9 fa-vorably modulates left ventricle proteome and related signaling pathways involved in post – myocardial infarction recovery
Prognosis after myocardial infarction (MI) varies greatly depending of the extent of damaged area and the management of biological processes during recovery. Reportedly, the inhibition of the pro-inflammatory S100A9 reduces myocardial damage after MI. We hypothesize that S100A9 blockade induces chan...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD033683 | Pride
Hypertrophy Apoptosis Cardiac repair S100a9 Myocardial infarction 
ProteomicsDefining the cardiac fibroblast secretome in the post-MI heart in vivo
Cardiac fibrosis is a common feature of ischemic heart disease and cardiac fibroblasts (CF) are key players in cardiac remodeling of the injured heart after myocardial infarction (MI). Fibrosis increases myocardial stiffness, thereby impairing cardiac function, which ultimately progresses to end-sta...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-25 | PXD053791 | Pride
Intercellular crosstalk Proteomics Turboid Myocardial infarction In vivo secretome 
ProteomicsHuman myocardial tissue proteomics associated with late gadolinium enhancement burden in hypertrophic cardiomyopathy
This project investigates myocardial tissue proteomic remodeling associated with cardiac magnetic resonance-defined late gadolinium enhancement burden in patients with hypertrophic cardiomyopathy. Myocardial tissue samples were obtained from patients undergoing septal myectomy, and protein abundance...
ORGANISM(S): Homo sapiens (Human) 
2026-07-22 | PXD079292 | Pride
Human myocardial tissue proteomics associated with late gadolinium enhancement burden in hypertrophic cardiomyopathy 
ProteomicsDysferlin stabilizes membrane nanodomains of cardiomyocytes after myocardial infarction
BACKGROUND: Despite significant advances in acute care medicine, myocardial infarction (MI) remains a predominant cause of premature death and heart failure. In the infarct border zone, cardiomyocytes are exposed to high biomechanical stress that impairs the integrity of the sarcolemmal membrane. He...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD060259 | Pride
Myocardial ischemia Proteomics Cardiomyocytes Connexin-43 Dysferlin Intracellular membranes Myocardial infarction 
ProteomicsMyocardial Proteome in Human Heart Failure with Preserved Ejection Fraction
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2025-04-11 | PXD060431 | Pride
Oxidative phosphorylation Metabolism Fatty acids Proteomics Obesity Myocardium Molecular medicine : heart failure 
ProteomicsPig myocardial tissue quantitative proteomics
Proteomics study of the anthracycline-induced cardiotoxicity in in pigs with pre-existing left ventricular (LV) pressure overload. Large White pigs (2-month-old males and females) were used to induce LV pressure overload via supravalvular aortic stenosis (or sham operation). After 4 months, animals ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-02-05 | PXD056684 | Pride
Myocardial tissue Lc-msms Tmt10plex isobaric labeling Quantitative proteomics Pig 
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