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ProteomicsPosition-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin
Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tissues through the proteolytic cleavage of an exposed reactive centre loop (RCL) by neutrophil elastase (NE). We previously demonstrated that RCL-localised Asn347-linked N-glycans impact NE proteolysis, but a comp...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD046405 | Pride
Glycosylation O-glycosylation Corticosteroid-binding globulin Cortisol N-glycosylation Proteolysis Reactive centre loop Neutrophil elastase 
ProteomicsGlycoproteome of Elongating cotton fiber cells
Glycoproteins isolated from elongating cotton fiber cells were analyzed using 2D-PAGE followed by MALDI TOF/TOF based protein identification. Protein isoforms were identified using Tandem mass spectrometry. Lectin based Glycopeptide enrichment strategy followed by PNGase catalyzed deglycosylation re...
ORGANISM(S): Gossypium 
2015-11-25 | PXD002849 | Pride
2d page Glycopeptide approach N-linked glycosylation site assignment 
ProteomicsOxonium ion guided analysis of quantitative proteomics data reveals site-specific O-glycosylation of anterior gradient protein 2 (AGR2)
Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the characteristic pattern of oxonium ions in glycopeptide fragmentation spectra had been used to assign different sets of glycopeptides. In part...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025805 | Pride
Glycoproteomics  tmt labeling  oxonium ion  lc−ms/ms  o-glycosylation  colorectal cancer  agr2 
UnknownGPQuest: A Spectral Library Matching Algorithm for Site-Specific Assignment of Tandem Mass Spectra to Intact N-glycopeptides.
Not available
S-EPMC4721644 | biostudies-literature
ProteomicsAllotype-specific glycosylation and cellular localization of HLA class I proteins
Presentation of self- and foreign peptide antigens by human leukocyte antigen (HLA) complexes at the cell surface is a key process in our immune response. The alpha-chain, the part of the HLA class I complex that contains the peptide binding groove, is one of the most polymorphic proteins in the hum...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD023684 | Pride
Glycoproteomics Mhc Hla 
ProteomicsA comprehensive, open-source platform for mass spectrometry based glycoproteomics data analysis
Glycosylation is among the most abundant and diverse protein post-translational modifications (PTMs) identified to date. The structural analysis of this PTM is challenging due to the diverse monosaccharides which are not conserved among organisms, the branched nature of glycans, their isomeric struc...
ORGANISM(S): Homo sapiens (Human) 
2017-09-19 | PXD006031 | Pride
Human Lc-ms Plasma 
UnknownDevelopment of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment.
Not available
S-EPMC12371524 | biostudies-literature
UnknownDevelopment of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment.
Not available
S-EPMC11741357 | biostudies-literature
UnknownElectron transfer dissociation (ETD): the mass spectrometric breakthrough essential for O-GlcNAc protein site assignments-a study of the O-GlcNAcylated protein host cell factor C1.
Not available
S-EPMC3988289 | biostudies-literature
ProteomicsOn-tissue spatially-resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape
Here we present an approach to identify N-linked glycoproteins and deduce their spatial localization using a combination of MALDI N-glycan MSI and spatially-resolved glycoproteomics. We subjected glioma biopsies to on-tissue PNGaseF digestion and MALDI-MSI and found that the glycan HexNAc4-Hex5-NeuA...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-05-04 | PXD025537 | Pride
Glioblastoma Spatially resolved glycoproteomics Glycoproteomics Glycan imaging Haptoglobin Sialic acid Spatially resolved glycoproteomicsglycan imaging Maldi-msi Hypersialylation 
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