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ProteomicsCellular proteomic profiling using proximity labelling by TurboID-NES in microglial and neuronal cell lines.
Different brain cell types play distinct roles in brain development and disease via cellular mechanisms. Molecular characterization of these cellular mechanisms using cell type-specific approaches, particularly at the protein (proteomic) level, can provide biological and therapeutic insights. Conven...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036744 | Pride
Bv2 N2a Inflammation Proteomics Turboid 
ProteomicsN2a cell lysate, PLA2G6 IP, LC-MS/MS
Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer
ORGANISM(S): Mus musculus (Mouse) 
2026-02-04 | PXD057620 | Pride
N2a cell lysate Pla2g6 ip Lc-ms/ms 
ProteomicsSurveyance of apparent proteome unfolding curves via thiol labelling under HSP70 inhibition
Census of apparent proteome unfolding curves following urea denaturation in cell lysate derived from control of VER155008-treated N2a cells using thiol reactivity probe tetraphenylethene maleimide (TPE-MI).
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD030567 | Pride
Denaturation Protein folding 
ProteomicsSCX_MS raw files and RP_MS raw files
A novel one-dimensional on-line pH gradient-eluted strong cation exchange (SCX)-nano-ESI-MS/MS method was developed for protein identification and tested with mixture of six standard proteins, total lysate of HuH7 and N2a cells, as well as membrane fraction of N2a cells. This method utilized an on-l...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-01-28 | PXD003438 | Pride
Strong cation exchange Ph gradient 
ProteomicsEvaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides
Chronic low dose exposure to organophosphorus pesticides is associated with risk of neurodegenerative disease. The mechanism of neurotoxicity is unknown, though it is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-17 | PXD027203 | Pride
Transglutaminase Dansyl cadaverine Isopeptide Dansyl-aminohexyl qqiv Protein prospector Map-rich tubulin Neurodegenerative disease Crosslinks 
UnknownRabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry.
Not available
S-EPMC8491160 | biostudies-literature
UnknownThe Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APPswe Cell Model of AD.
Not available
S-EPMC5893754 | biostudies-literature
ProteomicsEnhancing Membrane Protein Identification Using a Simplified, Centrifugation and Detergent-based Membrane Extraction Approach
Membrane proteins may act as transporters, receptors, enzymes and adhesion-anchors, accounting for nearly 70% of pharmaceutical drug targets. Difficulties in efficient enrichment, extraction and solubilization still exist because of their relatively low abundance and poor solubility. A simplified me...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-27 | PXD007731 | Pride
Sequence coverage Identification Mass spectrometry Enrichment Membrane proteins 
ProteomicsA massively parallel reporter assay reveals novel features and players of RNA localization in neurons
This experiment aims to identify the RNA-binding proteome that is pulled-down from a cellular lysate with biotinylated RNA probes.
ORGANISM(S): Mus musculus (Mouse) 
2021-04-30 | PXD025492 | Pride
Mpra Pull-down Rna localization 
ProteomicsEnhancing Membrane Protein Identification Using a Simplified, Centrifugation and Detergent-based Membrane Extraction Approach
Membrane proteins may act as transporters, receptors, enzymes and adhesion-anchors, accounting for nearly 70% of pharmaceutical drug targets. Difficulties in efficient enrichment, extraction and solubilization still exist because of their relatively low abundance and poor solubility. A simplified me...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-01-31 | PXD008456 | Pride
Sequence coverage Identification Mass spectrometry Enrichment Membrane proteins 
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