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ProteomicsDevelopment and characterization of selective FAK inhibitors and PROTACs with in vivo activity
Focal adhesion kinase (FAK) is an attractive drug target due to its overexpression in cancer. FAK functions as a non-receptor tyrosine kinase and scaffolding protein, coordinating several downstream signaling effectors and cellular processes. While drug discovery efforts have largely focused on targ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD039828 | Pride
Fak Inhibitor Protac Degrader 
TranscriptomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-64195 | biostudies-arrayexpress
TranscriptomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [RNA-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-63497 | biostudies-arrayexpress
GenomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [ChIP-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-64190 | biostudies-arrayexpress
TranscriptomicsA putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs
Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. An experimental purification in which a presumed RNA binding protein was used for an RNA immunoprecipitation and microarray analysis (RIP-CHIP). Total cell extracts w...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-16942 | biostudies-arrayexpress
ProteomicsRapid and direct control of target protein levels with VHL-recruiting dTAG molecules
Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAGV-1, an exclusively selective VHL-recruiting dTAG molecule,...
ORGANISM(S): Homo sapiens (Human) 
2020-09-21 | PXD018937 | Pride
Proteomics Protac Dtag Degraders 
TranscriptomicsThe RNA binding protein RBM38 (RNPC1) regulates splicing during late erythroid differentiation
Alternative pre-mRNA splicing is a prevalent mechanism in mammals that promotes proteomic diversity, including expression of cell-type specific protein isoforms. We characterized a role for RBM38 (RNPC1) in regulation of alternative splicing during late erythroid differentiation. We used an affyme...
ORGANISM(S): Homo sapiens 
2013-07-29 | E-GEOD-49293 | biostudies-arrayexpress
TranscriptomicsA compendium of RNA-binding motifs for analysis of gene regulation
RNA binding proteins are key regulators of gene expression, yet only a small fraction of these proteins has been functionally characterized. Here, we report the first large-scale analysis of the RNA motifs recognised by RNA binding proteins, encompassing 205 distinct proteins from 24 diverse eukary...
ORGANISM(S): synthetic construct 
2013-05-10 | E-GEOD-41235 | biostudies-arrayexpress
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