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ProteomicsCalsequestrins in skeletal and cardiac muscle from adult Danio rerio.
All vertebrates have multiple genes encoding for different CASQ isoforms. Increasing interest has been focused on mammalian and human CASQ genes since mutations of both cardiac (CASQ2) and skeletal (CASQ1) isoforms cause different, and sometime severe, human pathologies Danio rerio (zebrafish) is a ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2015-11-10 | PXD002455 | Pride
Cardiac Muscle Skeletal Calsequestrins 
ProteomicsER stress response in hepatocytes upon Plasmodium infection
Upon infection of a mammalian host, Plasmodium parasites first replicate inside hepato-cytes, generating thousands of new parasites. Although Plasmodium intra-hepatic devel-opment represents a substantial metabolic challenge to the host hepatocyte, how infected cells respond to and integrate this st...
ORGANISM(S): Homo sapiens (Human) 
2016-04-20 | PXD002269 | Pride
Huh7 plasmodium infection 
ProteomicsDbf4-dependent kinase (DDK) and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis
DNA repair by homologous recombination is under stringent cell cycle control. This includes the last step of the reaction, disentanglement of DNA joint molecules (JMs). Previous work has established that JMs resolving nucleases are activated specifically at the onset of mitosis. In case of budding y...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-21 | PXD005356 | Pride
Ddk Yeast Dna repair 
ProteomicsSubstrates of human TRAP complex
While the Sec61-complex in the membrane of the human endoplasmic reticulum facilitates translocation of all precursor polypeptides with amino-terminal signal peptides or transmembrane helices, the Sec61-associated translocon-associated protein (TRAP)-complex supports translocation of only a subset o...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD008178 | Pride
Sec61 complex Ms Hela cells Er protein import Trap complex 
ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links part 2 of 2: AP-MS DATA (QUBIC)
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-13 | MSV000079577 | MassIVE
ProteomicsMicroplastics and algal toxins in mussels: A dual threat to marine health and seafood safety
The molecular responses of marine mussels to contamination with emergent contaminants in marine ecosystems - the biotoxin Okadaic Acidc and Microplastics - was investigated in experiments with live mussels of the species Perna perna. In total 24 independent biological samples, from 4 experimental co...
ORGANISM(S): Perna perna 
2026-07-16 | PXD071829 | Pride
Shotgun proteomics  perna perna  environmental contamination  ecotoxicology 
ProteomicsTargeting of precursor polypeptides to the human ER
Various pathways can target nascent or fully synthesized precursor polypeptides to the human endoplasmic reticulum (ER). Typically, they involve cytosolic proteins or complexes and their respective receptors on the ER surface. The signal recognition particle (SRP) and the heterodimeric SRP-receptor...
ORGANISM(S): Homo sapiens (Human) 
2020-03-06 | PXD011993 | Pride
Hela Snd2 Wrb/caml Sr 
ProteomicsCell type-resolved quantitative proteomics of mouse liver
Proteomics of pure cell populations provides a powerful approach to globally investigate biological function of individual cell types in mammalian organs. Here, we applied latest mass spectrometry techniques for in-depth proteomic analysis of freshly isolated hepatic cell types (HC-types) from murin...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084937 | MassIVE
ProteomicsSubstrates of human Sec62/Sec63 complex
The Sec61-associated Sec62/Sec63 complex supports translocation of only a subset of precursor polypeptides, i.e. in a substrate-specific manner. To characterize Sec62/Sec63-dependent precursors, we combined siRNA-mediated Sec62 or Sec63 depletion in Hela cells or CRISPR/Cas9-mediated knock-down in H...
ORGANISM(S): Homo sapiens (Human) 
2020-03-06 | PXD012078 | Pride
Hela Er protein import Hek 293 
ProteomicsS.cerevisiae - Whole organism, Intensity (Nagaraj,mcp,2012)
abundance based on MAPPED_BY_AUTHORS, intensity, Interaction consistency score: 11.4, Coverage: 59
ORGANISM(S): 4932 
2012-00-00 | 2521601554 | PAXDB
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