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ProteomicsUrine-HILIC – An automated sample preparation for bottom-up urinary proteome profiling in clinical proteomics
Urine provides a diverse source of information related to health status and is ideal for clinical proteomics because of its ease of collection. To date, there is no standard operating procedure for reproducible and robust urine sample processing for mass spectrometry-based clinical proteomics. To ad...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043925 | Pride
Automated sample preparation  clinical proteomics  swath-ms (dia)  urinary proteomics  hilic 
ProteomicsProteomic Analysis identifies dysregulated proteins and associated molecular pathways in a cohort of South African Gallbladder cancer patients
Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specific and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little known about the molecular mechanisms associated with GBC, especially...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029877 | Pride
Swath Lc-ms Plasma Gallbladder 
ProteomicsSWATH-MS based proteomic profiling of Pancreatic Ductal Adenocarcinoma tumours reveals the interplay between the extracellular matrix and related intracellular pathways
Pancreatic cancer accounts for 2.8% of new cancer cases worldwide and is projected to become by 2030 the second leading cause of cancer-related deaths. Patients of African ancestry appear to be at an increased risk for pancreatic ductal adenocarcinoma (PDAC), with worse severity and outcomes. The pu...
ORGANISM(S): Homo sapiens (Human) 
2020-09-30 | PXD019549 | Pride
Pancreatic cancer Extracellular matrix Swath-ms 
ProteomicsProteomic analysis identifies dysregulated proteins in albuminuria: a South African pilot study
Chronic kidney disease remains an unmet clinical challenge. It is only detected at advanced stages by current markers. Therefore, early detection of chronic kidney disease is vital. In this study, we profiled the urinary proteome in patients with albuminuria with well-preserved eGFR. We identi-fied ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054170 | Pride
Urinary proteomics  albuminuria  chronic kidney disease  biomarker Ne 
ProteomicsAssessing the dynamics and macromolecular interactions of the intrinsically disordered protein YY1
YY1 is a ubiquitously expressed, intrinsically disordered transcription factor involved in neural development. The oligomeric state of YY1 varies depending on the environment. These changes may alter its DNA binding ability and hence its transcriptional activity. In addition to its oligomeric state,...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038431 | Pride
Yy1 Intrinsic disorder Foxp2 Dna binding Protein-protein interactions 
ProteomicsMag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome
Membrane-bound particles in plasma are composed of exosomes, microvesicles, and apoptotic bodies and represent ~1-2% of the total protein composition. Proteomic interrogation of this subset of plasma proteins augments the representation of tissue-specific proteins, representing a “liquid biopsy,” wh...
ORGANISM(S): Homo Sapiens 
PXD042947 | panorama
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