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MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
MetabolomicsMulti-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views ...
2020-01-23 | MTBLS721 | MetaboLights
MetabolomicsNano-Kinetic Implant Surface Mediates Osteo-Antibacterial Synergy through Electromagnetic-Mechanical Coupling
This untargeted LC-MS/MS metabolomics study investigates metabolic differences between laboratory reference Staphylococcus aureus and periprosthetic implant-associated Staphylococcus aureus in bacterial suspension samples associated with implant surface lavage. The metabolomics dataset forms part of...
2026-08-28 | MTBLS15301 | MetaboLights
MetabolomicsNano-silicon dioxide reduced soil organic pollutant contents

Composite organic pollutant residues had caused considerable threats to soil systems, and the nano-SiO2 could decrease composite organic pollutant residue dissipations in soil systems

2025-11-24 | MTBLS12675 | MetaboLights
MetabolomicsNano-silicon dioxide declined organic pollutant contents in plant samples

Composite organic pollutant residues caused considerable threats to soil systems, and the nano-SiO2 could decrease organic pollutant residuecontents in plant systems

2025-11-24 | MTBLS12683 | MetaboLights
MetabolomicsNano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis

Many patients are suffering from atherosclerosis without typical risk factors, which can cause severe cardiovascular complications. Trimethylamine N-oxide (TMAO), derived from gut microbes, is a key unconventional contributor to the development of atherosclerosis. Here we present a stra...

2025-10-25 | MTBLS12426 | MetaboLights
MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Data-independent acquisition)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2959 | MetaboLights
MetabolomicsNon-targeted LC–MS metabolomics of human left atrial appendage tissue with high vs low myocardial micro(nano)plastic burden

Non-targeted metabolomics profiling was performed on human left atrial appendage tissue obtained from cardiac surgery patients. Samples were grouped by myocardial nanoplastic (NP) burden (High vs Low). Polar metabolites were analyzed by UHPLC–Orbitrap MS in both positive and negative ionization m...

2026-03-28 | MTBLS14056 | MetaboLights
MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Mixed-mode column chromatography)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2497 | MetaboLights
UnknownPerformance comparisons of nano-LC systems, electrospray sources and LC-MS-MS platforms.
Not available
S-EPMC3886563 | biostudies-literature
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