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MetabolomicsBiological Effects of Amphiphilic Copolymer Nanoparticle-Encapsulated Multi-target Chemotherapeutic Drugs on MCF-7 Human Breast Cancer Cells
INTRODUCTION: Amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs have attracted considerable attention due to their favorable drug efficiency and potential application prospect. Studies have shown that an amphiphilic copolymer, methoxypoly(ethylene glycol)-poly(lacti...
2018-05-03 | MTBLS430 | MetaboLights
TranscriptomicsGene Expression in Gold Nanoparticle Oligonucleotide Complexes treated Primary Immune Cells
Gold nanoparticle (Au—NP) oligonucleotide complexes hold considerable promise as an approach for manipulating intracellular gene regulation. We show that the uptake and intracellular fate of Au—NP oligonucleotide complexes is associated with endocytosis and signal transduction. A transcriptomeâ€...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-20677 | biostudies-arrayexpress
ProteomicsIdentification of Putative Kidney-Derived Proteins in Plasma using Nanoparticle Enrichment
Many diseases, including diabetes and hypertension, can lead to kidney damage, often resulting in long-term health complications and organ failure. Both animal and human studies have documented a causal relationship between high dietary sodium intake and elevated blood pressure. We explored a proteo...
ORGANISM(S): Papio hamadryas 
2026-03-30 | PXD071248 | Pride
Lc-msms Plasma Tissue-leakage proteins Diet challenge Kidney Baboon Non-human primates Sodium Nanoparticle affinity enrichment 
ProteomicsNanoparticle protein corona LC-MS/MS
Engineered nanoparticles for biomedical applications require increased effectiveness in targeting specific cells while preserving non-target cells’ safety. Native nanoparticles entering a protein-rich liquid media quickly form a macromolecular structure called protein corona. This protein structure...
ORGANISM(S): Bos taurus (Bovine) 
2017-02-28 | PXD004636 | Pride
Protein corona (pc) Nanoparticle (np) Lc-ms/ms 
TranscriptomicsGene expression in the spleen; effect of maternal exposure to carbon black nanoparticle
The aim of this study was to investigate the effects of administration of carbon black nanoparticle (CB-NP) to pregnant mice on the development of lymphoid tissues in infantile mice. Pregnant ICR mice were treated with a suspension of CB-NP 95 microg/kg/time) by intranasal instillation, twice, on ge...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-50432 | biostudies-arrayexpress
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-22 | PXD066851 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
ProteomicsProfiling glycoproteins enriched by surface functionalised nanoparticles
Biologically relevant biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for glycoproteomic analysis due to their complex protein composition and the wide dynamic range of protein abundances. Nanoparticle-based (NP) enrichment has previously shown promise in enha...
ORGANISM(S): Homo sapiens (Human) 
2026-01-09 | PXD059675 | Pride
Cerebrospinal fluid Glycoproteome Nanoparticle enrichment Human plasma Glycopeptide enrichment 
ProteomicsPlasma Proteome Profiling via Nanoparticle Protein Corona and Direct Infusion Mass Spectrometry
a new hybrid method, which integrates direct infusion shotgun proteome analysis (DISPA) with nanoparticle (NP) protein coronas enrichment for high throughput and efficient plasma proteomic profiling.
ORGANISM(S): Human Plasma 
2024-02-06 | MSV000094026 | MassIVE
UnknownSynthesis of a High Affinity Complementary Peptide-Polymer Nanoparticle (NP) Pair Using Phage Display.
Not available
S-EPMC9109703 | biostudies-literature
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-10-22 | PXD066813 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
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