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ProteomicsHigh-throughput plasma/serum proteomics by coupling nanoparticle protein corona-based sample preparation and capillary zone electrophoresis-tandem mass spectrometry
A high-throughput workflow for bottom-up proteomics (BUP) of human plasma using capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) and nanoparticle protein corona-assisted sample preparation is presented. The streamlined approach enabled the identification and quantification of hun...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-08-04 | PXD063043 | Pride
Nanoparticle protein corona Bottom-up proteomics High-throughput Cze-ms/ms Biomarker 
ProteomicsTop-down Nanoparticle-corona by cIEF-MS/MS
In the rapidly evolving field of nanomedicine, understanding the interactions between nanoparticles and biological systems is crucial. A pivotal aspect of these interactions is the formation of a protein corona when nanoparticles are exposed to biological fluids, which significantly influences their...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD052764 | Pride
Proteoforms Top-down proteomics Cief-ms/ms Nanoparticles Post-translational modifications Nanomedicine Protein corona 
ProteomicsCryo-Electron Microscopy Shows Absence of Conventional Protein Corona on Lipid Nanoparticle Surfaces
Upon exposure to biological fluids, nanoparticles rapidly acquire a “protein corona”, a layer of adsorbed biomolecules, predominantly proteins. This layer significantly impacts nanoparticle pharmacokinetics and biodistribution, making detailed characterization vital for designing safe, and targeted ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD070622 | Pride
Cryo-tem Lipid nanoparticles Protein corona Extracellular vesicles Corona shell Fusion 
ProteomicsDeep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules
The protein corona, a dynamic biomolecular layer that forms on nanoparticle (NP) surfaces upon exposure to biological fluids is emerging as a valuable diagnostic tool for improving plasma proteome coverage analyzed by liquid chromatography-mass spectrometry (LC-MS/MS). Here, we show that spiking pho...
ORGANISM(S): Homo sapiens (Human) 
2024-10-15 | PXD053359 | Pride
Protein corona Top down proteomics Human plasma Bottom up proteomics Nanoparticles 
ProteomicsIn situ Analysis of Nanoparticle Soft Corona and Dynamic Evolution
How soft corona i.e., the protein corona’s outer layer contributes to “biological” identity of nanomaterials (NMs) is largely unknown due to a longstanding challenge in capturing protein composition of the soft corona in situ. We herein develop an in situ “Fishing” method that can monitor the dynami...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD033976 | Pride
Protein corona Mouse serum 
ProteomicsNanoparticle protein corona LC-MS/MS
Engineered nanoparticles for biomedical applications require increased effectiveness in targeting specific cells while preserving non-target cells’ safety. Native nanoparticles entering a protein-rich liquid media quickly form a macromolecular structure called protein corona. This protein structure...
ORGANISM(S): Bos taurus (Bovine) 
2017-02-28 | PXD004636 | Pride
Protein corona (pc) Nanoparticle (np) Lc-ms/ms 
ProteomicsPhotocatalytic proximity labeling technology for nanoparticle protein corona
We designed a photocatalytic proximity labeling technology for in situ labeling of corona proteins. When nanoparticles were exposed in plasma, they were immediately irradiated to induce the photocatalytic reaction, in which the inner Ce6 activated BP in the outer layer. BP was then released from nan...
ORGANISM(S): Mus Musculus 
2022-06-23 | PXD034930 |
ProteomicsNanoparticle Elasticity Affects Systemic Circulation lifetime by Modulating the Adsorption of Apolipoprotein A-I in Corona Formation
Nanoparticle elasticity plays crucial roles in determining nanoparticles’ physiological performances. However, the underlying mechanisms by which nanoparticle elasticity does so remain unknown.Using core-shell nanoparticles with a same PEGylated lipid bilayer shell yet cores differing in elasticity ...
ORGANISM(S): Mus Musculus 
2022-05-20 | PXD034004 |
ProteomicsViral corona - The project introduces teh concept of a viral corona similarly to the nanoparticle protein corona
The project introduces teh concept of a viral corona similarly to the nanoparticle protein corona
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Human respiratory syncytial virus (strain RSB642) 
2019-04-11 | PXD009521 | Pride
Protein corona Viral protein corona 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-22 | PXD066851 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
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