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TranscriptomicsBidirectional manipulation of SF-1 (NR5A1) in NCI-H295R cells
SF-1 (NR5A1) was overexpressed (Over) or knocked down with shRNA (shRNA) in NCI-H295R human adrenocortical tumor cells and differential global gene expression analysed 48 hours later using Affymetrix GeneChip Human Gene 1.0ST arrays. Over: 5 million cells were transfected (Amaxa Nucleofection) with ...
ORGANISM(S): Homo sapiens 
2011-01-11 | E-GEOD-26529 | biostudies-arrayexpress
TranscriptomicsSF-1 and RNF31 knockdown and forskolin treatment
The human adrenocortical carcinoma cell line NCI-H295R treated with siRNA targeting SF-1 or RNF31 with luciferase-targeting siRNA as control. Combined with forskolin treatment.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MEXP-3259 | biostudies-arrayexpress
GenomicsThe role of NFATc4 on aldosterone production in NCI-H295R human adrenocortical cell line
The role of NFATc4 on aldosterone production in NCI-H295R human adrenocortical cell line
PRJNA937244 | ENA
GenomicsGene expression profiles of human adrenocortical NCI-H295R cells treated with cortisol biosynthesis inhibitors
Gene expression profiles of human adrenocortical NCI-H295R cells treated with cortisol biosynthesis inhibitors
PRJNA990799 | ENA
GenomicsGene expression data from NCI-H295R cell line treated with rottlerin samples.
Gene expression data from NCI-H295R cell line treated with rottlerin samples.
PRJNA1076239 | ENA
TranscriptomicsThe role of NFATc4 on aldosterone production in NCI-H295R human adrenocortical cell line
To investigate the role of NFATc4 in aldosterone production, we created NFATc4 knock-out NCI-H295R cell line and overexpressed active NFATc4 in wild type NCI-H295R cells. We then analyzed the transcriptome of the four cell types.
ORGANISM(S): Homo sapiens 
2023-05-12 | GSE225735 | GEO
ProteomicsCalcineurin increases expression of aldosterone synthase via dephosphorylation of NFATc4
The mineralocorticoid hormone, aldosterone, is secreted by the adrenal zona glomerulosa (ZG) in response to high plasma K+ and hypovolemia and promotes renal Na+ reabsorption and K+ secretion. Hence, the regulation of aldosterone secretion is critical for the control of ion homeostasis and blood pre...
ORGANISM(S): Homo sapiens (Human) 
2023-05-25 | PXD027856 | Pride
Nci-h295r Calcineruin Tacrolimus Aldosterone Cn Potassium Adrenal gland 
ProteomicsProteomic Analysis of Huh7, HIEC6, and NCI-H295R cells using High-affinity anti-Golm1 mAb by IP-MS.
we conducted IP-MS strategy to screen its interacting proteins. High-affinity anti-Golm1 mAb and IgG were used in multiple cell lines including Huh7, HIEC6, and NCI-H295R cells. Proteins with more than two peptide segments enriched or exclusively within the Golm1 group were identified as putative in...
ORGANISM(S): Homo sapiens (Human) Homo sapiens 
2026-03-23 | PXD061115 | Pride
Golm1 ip-ms 
TranscriptomicsGene expression data from NCI-H295R cell line treated with rottlerin samples.
Pediatric adrenocortical tumor (ACT) is a rare neoplasm with high heterogeneity, exhibiting an incidence 10 to 15 times higher in the south and southeast regions of Brazil when compared to the global incidence.In this context, our aim was to analyze the gene expression profile in the adrenocortical ...
ORGANISM(S): Homo sapiens 
2024-02-18 | GSE255729 | GEO
TranscriptomicsGene expression profiles of human adrenocortical NCI-H295R cells treated with cortisol biosynthesis inhibitors
We have recently identified a set of benzimidazolylurea derivatives including a representative compound (designated as CJ28), which inhibit both cortisol production and de novo cholesterol biosynthesis. To evaluate its putative mode-of-actions, we examined genome-wide RNA expression profiles of huma...
ORGANISM(S): Homo sapiens 
2023-07-11 | GSE236435 | GEO
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