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ProteomicsNEAT PLASMA PROTEOMICS: GETTING THE BEST OUT OF THE WORST
Plasma proteomics holds immense potential for clinical research and biomarker discovery, serving as a non-invasive "liquid biopsy" for tissue sampling. Mass spectrometry (MS)-based proteomics, thanks to improvement in speed and robustness, emerges as an ideal technology for exploring the plasma prot...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD047857 | Pride
Plasma Dia-nn Dia Extracellular vesicles Timstof pro 
ProteomicsComparison of deep plasma proteome enrichment methods
Plasma is a complex biological fluid containing extracellular vesicles (EVs), residual platelets, and soluble proteins, all of which can serve as biomarkers for pathological conditions. While conventional plasma proteomics typically identifies hundreds of proteins, recent enrichment strategies have ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD063673 | Pride
Enrichplus Proteograph Magnet Timstof Enrichment Plasma Evs Lc-ms/ms 
ProteomicsBenchmarking plasma from clinical and preclinical models
The push for new clinical biomarkers has seen rapid innovation in biofluid analysis, particularly for plasma. For mass-spectrometry (MS)-based analysis, achieving depth and quantitative accuracy whilst ensuring throughput continues to shape plasma methods development. Numerous workflows have emerged...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-07-27 | PXD072131 | Pride
Human Dia Serum Plasma Rat Orbitrap astral 
ProteomicsPlasma and Extracellular Vesicle Proteomic Signatures of traumatic brain injury (TBI) in Polytrauma
This study aimed to identify TBI-specific proteomic signatures in a heterogeneous cohort of critically injured polytrauma patients by analyzing the total plasma proteome and an extracellular vesicle (EV)-enriched plasma protein fraction. Severely injured adult trauma patients (ISS ≥16) were allo...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD079127 | Pride
Traumatic brain injury  extracellular vesicles  biomarkers  proteomics  polytrauma 
ProteomicsDeep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics
Raw data for the manuscript entitled "Deep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-19 | MSV000095086 | MassIVE
ProteomicsPre-analytical Sample Quality Determines Performance of Plasma Proteomics Workflows for Biomarker Discovery
This dataset contains mass spectrometry-based proteomic analyses of human plasma samples processed through five distinct proteomics workflows: neat plasma, perchloric acid precipitation with neutralization (PCA-N), and three bead-based enrichment methods (SAX magnetic beads, Sera Sil 700 magnetic be...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD063572 | Pride
Pre-analytical variables Lc-ms Plasma proteomics Bead-based enrichment Cellular contamination Sample quality 
ProteomicsA simplified perchloric acid workflow with neutralization (PCA N) for democratizing deep plasma proteomics at population scale - Submission02
Large scale plasma proteomics studies offer tremendous potential for biomarker discovery but face significant challenges in balancing analytical depth, throughput and cost effectiveness. We present an optimized perchloric acid based workflow with neutralization – PCA N – that addresses these limitat...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD062275 | Pride
Lc-msms Plasma 
ProteomicsA simplified perchloric acid workflow with neutralization (PCA N) for democratizing deep plasma proteomics at population scale - Submission01
Large scale plasma proteomics studies offer tremendous potential for biomarker discovery but face significant challenges in balancing analytical depth, throughput and cost effectiveness. We present an optimized perchloric acid based workflow with neutralization – PCA N – that addresses these limitat...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD062274 | Pride
Lc-msms Plasma 
ProteomicsPre-analytical Sample Quality Determines Performance of Plasma Proteomics Workflows for Biomarker Discovery part02
This dataset contains mass spectrometry-based proteomic analyses of human plasma samples processed through five distinct proteomics workflows: neat plasma, perchloric acid precipitation with neutralization (PCA-N), and three bead-based enrichment methods (SAX magnetic beads, Sera Sil 700 magnetic be...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD063593 | Pride
Pre-analytical variables Lc-ms Plasma proteomics Bead-based enrichment Cellular contamination Sample quality 
ProteomicsA simplified perchloric acid workflow with neutralization (PCA N) for democratizing deep plasma proteomics at population scale - Submission 3
Large scale plasma proteomics studies offer tremendous potential for biomarker discovery but face significant challenges in balancing analytical depth, throughput and cost effectiveness. We present an optimized perchloric acid based workflow with neutralization – PCA N – that addresses these limitat...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD062313 | Pride
Lc-msms Plasma 
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