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ProteomicsIncreased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity
HLA-presented antigenic peptides are central components of T cell-based immunity in infectious disease. Beside HLA molecules on cell surfaces, soluble HLA molecules (sHLA) are released in the blood suggested to impact cellular immune responses. We demonstrated that sHLA levels were significantly inc...
ORGANISM(S): Homo sapiens (Human) 
2022-11-23 | PXD029567 | Pride
Covid-19 Immunopeptidome Soluble hla 
ProteomicsIntegrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy
Clear cell renal cell carcinoma (ccRCC) is the dominant subtype of renal cancer. With currently available therapies, cure of advanced and metastatic ccRCC is achieved only in rare cases. Here, we developed a workflow integrating different -omics technologies to identify ccRCC-specific HLA-presented ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-03 | PXD017149 | Pride
Peptide vaccine Ccrcc Renal cell carcinoma Ligandomics Immunotherapy Cancer vaccine Kidney cancer Hla peptidomie 
ProteomicsImmunopeptidomics-guided warehouse design for peptide-based immunotherapy in chronic lymphocytic leukemia
In recent years the clinical success of T cell-based immunotherapy approaches has revolutionized treatment of solid tumors and hematological malignancies. However, still some patients do not respond to available therapies at all, others for limited time only. A promising low side-effect approach is ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024871 | Pride
Cll Hla Peptide warehouse Immunopeptidome 
ProteomicsUpstream open reading frames regulate proto-oncogene translation and encode HLA-presented immunogenic tumor antigens
Upstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data showed that uORFs can encode for biologically active proteins and human leucocyte antigen (HLA)-presented peptides and suggest their potential role in cancer cell ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025716 | Pride
Cancer Uorf Immunotherapy Immunopeptidomics Hla peptides 
ProteomicsThe HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy
Anti-leukemia immunity plays an important role for disease control and maintenance of tyrosine kinase inhibitor (TKI)-free remission in chronic myeloid leukemia (CML). Antigen-specific immunotherapy holds promise to strengthen immune control in CML, but requires the identification of CML-associated ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-11 | PXD010450 | Pride
Mass spectrometry Chronic myeloid leukemia Immunopeptidome 
ProteomicsUnveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling
The development of ribosomal profiling (Riboseq) revealed the immense coding capacity of human and viral genomes. Here, we used Riboseq to delineate the translatome of HIV-1 in infected CD4+ T cells. In addition to canonical viral protein coding sequences (CDSs), we identify 98 alternative open read...
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD043984 | Pride
Hiv-1 Ribosome profiling Immunopeptidome 
ProteomicsImmune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells
Persistent therapy-resistant leukemic progenitor cells (LPC) are a main cause of disease relapse and recurrence in acute myeloid leukemia (AML). Specific LPC-targeting therapies may thus improve treatment outcome of AML patients. We demonstrate that LPCs present human leukocyte antigen (HLA)-restric...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD038691 | Pride
Mass spectrometry Acute myeloid leukemia Immunotherapy Immunopeptidomics Leukemic progenitor cells Hla peptides 
ProteomicsMapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy
Identification of physiologically relevant peptide vaccine targets calls for the direct analysis of the entirety of naturally presented human leukocyte antigen (HLA) ligands, termed the HLA ligandome. In this study, we implemented this direct approach using immunoprecipitation and mass spectrometry ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD015748 | Pride
Acute myeloid leukemia Lc-msms 
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