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Proteomics¬The EGFR/ErbB inhibitor neratinib promotes apoptosis and clearance by airway macrophages
Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in inflamed tissues. Inducing neutrophil apoptosis, an immunologically silent form of cell death, may be beneficial in ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-22 | PXD035125 | Pride
Neratinib Macrophage Neutrophil 
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant A549 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6483 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H358 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6485 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H2009 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6486 | biostudies-arrayexpress
GenomicsRNAseq of parental and neratinib resistant 5637 and OVCAR8 cells with or withour neratinib treatment
RNAseq of parental and neratinib resistant 5637 and OVCAR8 cells with or withour neratinib treatment
PRJNA528648 | ENA
TranscriptomicsRNAseq of parental and neratinib resistant 5637 and OVCAR8 cells with or withour neratinib treatment
Pan-HER TKI neratinib has demonstrated clinical activity in patients with HER2-mutant cancers. However responses are heterogenoeus and not generally prolonged, suggesting de-novo and acquired resistance to neratinib. To study mechanisms of resistance to neratinib we generated neratinib resistant cel...
ORGANISM(S): Homo sapiens 
2020-01-07 | GSE128730 | GEO
ProteomicsThe pan-HER kinase inhibitor Neratinib modulates plant defense signaling by covalent targeting of an Arabidopsis epoxide hydrolase
The goal of this project was to identify the target of the human covalent kinase inhibitor drug neratinib in Arabidopsis samples. To this end we applied activity-based protein profilling using the neratinib alkyne derivative.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Homo sapiens (Human) 
2023-04-21 | PXD019640 | Pride
Abpp Inhibitor Plant immunity Neratinib Kinase 
ClinicalStudy of Neratinib +Trastuzumab or Neratinib + Cetuximab in Patients With KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer by HER2 Status
This is a phase II trial to examine the efficacy of neratinib plus trastuzumab or neratinib plus cetuximab in patients with "quadruple wild-type" (all RAS/NRAS/BRAF/PIK3CA wild-type), metastatic colorectal cancer based on HER2 status (amplified, non-amplified [wild-type] or mutated). Patients must h...
2267768 | ecrin-mdr-crc
UnknownPharmacokinetics of neratinib during coadministration with lansoprazole in healthy subjects.
Not available
S-EPMC5306479 | biostudies-literature
UnknownNeratinib for HER2-positive breast cancer with an overlooked option.
Not available
S-EPMC10559443 | biostudies-literature
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