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ProteomicsComparative and temporal characterization of LPS and blue light induced TLR4 signal transduction and gene expression in optogenetically manipulated endothelial cells
In endothelial cells (ECs), stimulation of Toll-like receptor 4 (TLR4) by the endotoxin lipopolysaccharide (LPS) induces the release of diverse pro-inflammatory mediators beneficial in controlling bacterial infections. However, their systemic secretion is a main driver of sepsis and chronic inflamma...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038764 | Pride
Lipopolysaccharide Chemotaxis Endothelial cells Mass spectrometry based proteomics Transmigration Toll-like receptor 4 Optogenetic control Pro-inflammatory proteins 
ProteomicsBeyond Pattern Recognition: TLR2 Promotes Chemotaxis, Cell Adhesion and Migration in THP-1 Cells
The interaction between monocytes and endothelial cells in inflammation is central to chemoattraction, adhesion, and transendothelial migration. Key players such as selectins and their ligands, integrins and other adhesion molecules and their function in these processes are well studied. Toll-like r...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041819 | Pride
Cell adhesion  cell migration Toll-like receptor 2  chemotaxis Thp-1 
ProteomicsImpact of PD1/PD-L1 Inhibition on Bone Remodeling: a Prospective Clinical Study and ex-vivo Validation.
Background Skeletal morbidity in cancer patients has a major impact on quality of life and preserving bone health while improving outcomes is an important goal of modern antitumor treatment strategies. Despite their widespread use in early disease stages, the effects of immune-checkpoint inhibitors ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD047604 | Pride
Bone remodeling  immune-checkpoint inhibitors  3d model  data-independent acquisition 
ProteomicsSeeding the meiotic DNA break machinery and initiating recombination on chromosome axes
Recombination-mediated linking of homologous chromosomes is a unique meiotic feature that enables the halving of chromosomal ploidy in sexual life cycles. Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) that are generated by focal multi-protein clusters that condense...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-23 | PXD042221 | Pride
Iho1 Phosphorylation 
ProteomicsStructure of cytoplasmic RNA polymerase II
Before RNA polymerase II (Pol II) can enter the nucleus, where it transcribes messenger RNA, it must first be assembled in the cytoplasm. We have performed proteomic and structural analysis of endogenous human cytoplasmic Pol II complexes, enriched in known biogenesis factors including RPAP2 and the...
ORGANISM(S): Homo sapiens (Human) 
2026-07-14 | PXD070852 | Pride
Rpap2 Xl-ms Gpn1. gpn3 Gdown1 Rna polymerase ii 
ProteomicsThe TLR10–Vitamin D Axis Facilitates Osteogenic DifferThe TLR10–Vitamin D Axis Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells in vitroentiation of Mesenchymal Stem Cells in vitro
Bone regeneration depends on the coordinated interplay between mesenchymal stem cells (MSCs), immune-derived signals, and processes of extracellular matrix (ECM) remodeling. While most Toll-like receptors (TLRs) evoke pro-inflammatory responses that impair osteogenesis, the role of the atypical, imm...
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD071139 | Pride
Osteogenic differentiation Vitamin d signaling Mesenchymal stem cells Toll-like receptor 10 
MetabolomicsFinger sweat analysis enables short interval metabolic biomonitoring in humans

Metabolic biomonitoring in humans is typically based on the sampling of blood, plasma or urine. Although established in the clinical routine, these sampling procedures are often associated with a variety of compliance issues and are impractical for performing time-course studies. The analysis of ...

2021-08-13 | MTBLS2772 | MetaboLights
MetabolomicsFinger sweat analysis enables short interval metabolic biomonitoring in humans

Metabolic biomonitoring in humans is typically based on the sampling of blood, plasma or urine. Although established in the clinical routine, these sampling procedures are often associated with a variety of compliance issues and are impractical for performing time-course studies. The analysis of ...

2021-08-13 | MTBLS2776 | MetaboLights
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