Neumann Hannah H

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Proteomics (3)
Metabolomics (1)

Organisms

Homo sapiens (2)
Mus musculus (2)
Escherichia coli (1)
Saccharomyces cerevisiae (1)

Repository

pride (3)
MetaboLights (1)

Tissue

Brain (3)
Cell culture (1)
Eye (1)

Disease

Medulloblastoma (2)
Medulloepithelioma (1)

Technology Type

Mass Spectrometry (3)
Shotgun proteomics (3)
Mass spectrometry (1)
SWATH MS (1)

Instrument Platform

6520 Q-TOF LC/MS (Agilent) (1)

Publication Date

2022 (2)
2016 (1)
2024 (1)

Metabolite Name

(-)-Epigallocatechin (1)
(.+/-.)-Lyoniresinol 2a-O-.beta.-D-glucopyranoside (1)
(.alpha.S,1S,2R)-.alpha.-Amino-2-carboxycyclopropaneacetic acid (1)
(1-Acetyloxy-3-hydroxy-6,8a-dimethyl-7-oxo-3-propan-2-yl-2,3a,4,8-tetrahydro-1H-azulen-4-yl) 4-hydroxybenzoate (1)
(1-Hydroxycyclohexyl)acetic acid (1)
(12Z)-9,10,11-Trihydroxyoctadec-12-enoic acid (1)
(17Z)-16-(Acetyloxy)-6-hydroxy-4,8,14-trimethyl-3,7-dioxo-18-norcholesta-17,24-dien-21-oic acid (1)
(2E)-N-(4-Acetamidobutyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide (1)
(2E,4E)-5-(6-((.beta.-D-Glucopyranosyloxy)methyl)-1-hydroxy-2,6-dimethyl-4-oxocyclohex-2-en-1-yl)-3-methylpenta-2,4-dienoic acid (1)
(2E,4E)-7,12-Dihydroxy-13-(hydroxymethyl)-3,5,7-trimethyltetradeca-2,4-dienedioic acid (1)
(2E,6E,10E,14S)-14-((2-O-.beta.-D-Glucopyranosyl-.beta.-D-glucopyranosyl)oxy)-2,6,10,14-tetramethylhexadeca-2,6,10,15-tetraenoic acid (1)
(2R,3R,4S,5S,6R)-2-Octoxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxane-3,4,5-triol (1)
(2S)-2-[(2R,3S,7R,8R,8aS)-2,3,4'-Trihydroxy-4,4,7,8a-tetramethyl-6'-oxospiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3,8-dihydrofuro[2,3-e]isoindole]-7'-yl]-3-methylbutanoic acid (1)
(2S)-4-Amino-2-hydroxybutanoic acid (1)
(3-(Hexopyranosyloxy)-2-((2Z)-pent-2-en-1-yl)cyclopentyl)acetic acid (1)
(3.beta.,5.Xi.,8.alpha.,9.beta.,10.alpha.,16.beta.)-16-Hydroxykauran-3-yl .beta.-D-glucopyranoside (1)
(3.beta.,5.Xi.,9.Xi.,18.Xi.)-3,19-Dihydroxyurs-12-ene-24,28-dioic acid (1)
(3S,4S,6aR,6bS,8R,8aR,12aS,14bR)-8-Hydroxy-4,6a,6b,11,11,14b-hexamethyl-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid (1)
(3S,6R,12S)-6-Benzyl-3-butan-2-yl-9-(6,7-dihydroxyoctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone (1)
(4-(.beta.-D-Glucopyranosyloxy)-2,6-bis(3-methylbut-2-en-1-yl)phenyl)(hydroxy)acetic acid (1)
(5-Chloro-1H-benzimidazol-2-yl)methanol (1)
(5.Xi.,9.Xi.,18.Xi.)-3-Oxolup-20(29)-ene-27,28-dioic acid (1)
(7E)-11-Hydroxy-4,5,8,13,13-pentamethyl-3-(2-methylpropyl)-3,3a,4,6a,9,10,11,11a,14a,15-decahydro-1H-[1,3]dioxolo[9,10]oxacyclododecino[2,3-d]isoindole-1,16(2H)-dione (1)
(9Z,12E)-15,16-Dihydroxyoctadeca-9,12-dienoic acid (1)
(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (1)
(E)-3,10-Dihydroxy-4,9-dimethyldodec-6-enedioic acid (1)
(E)-3-(4-Acetyloxy-2,3-dihydroxy-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)prop-2-enoic acid (1)
(E)-4-Hydroxy-4-[4-hydroxy-2-[(E)-6-hydroxyhept-1-enyl]cyclopentyl]but-2-enoic acid (1)
(E)-4-[4-[(E)-Hept-1-enyl]-2,5-dihydroxy-3-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-3-en-6-yl]-2-methylbut-2-enoic acid (1)
(E)-5-Hydroxyundec-2-enoic acid (1)

Lab affiliation

Section of Mass Spectrometric Proteomics, University Medical Center Hamburg eppendorf (2)
Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)

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Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. To unravel phenotypically relevant MB subtypes, we compiled a harmonized proteome dataset of 167 MBs and integrated findings with DNA methylation and N-glycome data. Six proteome MB sub...

ORGANISM(S): Homo sapiens (Human)

2024-06-05 | PXD039319 | Pride

ComBat HarmonizR enables the integrated analysis of independently generated proteomic datasets through data harmonization with appropriate handling of missing values

The integration of proteomic datasets, generated by non-cooperating laboratories using different LC-MS/MS setups can overcome limitations in statistically underpowered sample cohorts but has not been demonstrated to this day. In proteomics, differences in sample preservation and preparation strateg...

ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast)

2022-05-23 | PXD027467 | Pride

Swath Metastudy Missing values Dda Dia Tmt Data integration Ffpe Silac Tissue Harmonisazion Fresh-frozen Combat

Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma

Intraocular medulloepithelioma (IO-MEPL) is a rare embryonal ocular neoplasm, prevalently occurring in children. IO-MEPL share histomorphological features with CNS embryonal tumors with multilayered rosettes (ETMR), referred to as intracranial medulloepitheliomas. While Sonic hedgehog (SHH) and WNT ...

ORGANISM(S): Mus musculus (Mouse)

2022-02-15 | PXD028697 | Pride

Cancer Mouse model Hedghog signaling Intraocular medulloepethelioma Bottom up Wnt signaling

Metabolomic profiling of Fraxinus excelsior genotypes tolerant or susceptible to ash dieback disease reveals changes in iridoid glycosides

European common ash, Fraxinus excelsior L., is currently threatened by Ash dieback (ADB) caused by the fungus, Hymenoscyphus fraxineus. To detect and identify metabolites that may be products of pathways important in contributing to resistance against H. fraxineus we performed untargeted metabolomic...

2016-11-09 | MTBLS372 | MetaboLights

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