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MetabolomicsGinsenoside Rg5 protects against hypoxic neuronal injury
For metabolome analysis, major metabolic intermediates were analyzed with technical support from Applied Protein Technology Co., Ltd. (Shanghai, China) 17. Briefly, eight treated and untreated cell samples stored in liquid nitrogen were processed and separated by ultrahigh-performance liquid chromat...
2026-07-14 | MTBLS15037 | MetaboLights
ProteomicsLow glucose culture conditions alter neuronal energetics, mimicking in vivo studies
Neurons are almost exclusively cultured in media containing glucose at much higher concentration than found in the brain. To test whether “standard” hyperglycaemic culture conditions affect neuronal respiration compared to near- euglycemic conditions, we grew neuronal cultures with minimal glial con...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD059008 | Pride
Primary mouse neuron Cell culture Glucose Mitochondrial respiration Neurobasal media Neuronal bioenergetics 
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
TranscriptomicsImmunomagnetic purification of mES derived neuronal precursors increases neuronal migration and differentiation in vivo
All established protocols for differentiation of mouse and human pluripotent stem cells into specific neural subpopulations generate a considerable cellular heterogeneity that hampers experimental and clinical progress. In order to obtain a homogenous population of neuronal precursor cells and to st...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-35125 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuronal differentiation in two subtypes of SH-SY5Y
Background: SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signaling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehens...
ORGANISM(S): Homo sapiens 
2009-09-04 | E-GEOD-9169 | biostudies-arrayexpress
MetabolomicsThe Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient salvage remain elusive. Numerous ultrastructural studies have documented a plasma membrane invagination with a d...

2023-04-19 | MTBLS7006 | MetaboLights
TranscriptomicsGeminin knockdown in embryonic stem cell-derived neural precursors
Regulating the transition from lineage-restricted progenitors to terminally differentiated cells is a central aspect of nervous system development. Here, we investigated the role of the nucleoprotein Geminin in regulating neurogenesis at a mechanistic level during both Xenopus primary neurogenesis a...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-39657 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of mESCs differentiation time course toward neuronal lineage
mESC adapted to 2i/LIF conditions over four passages (8 days) before differentiation towards the neuronal lineage was induced using experimental conditions described in the literature (PMID: 12524553).
ORGANISM(S): Mus musculus 
2017-09-27 | E-MTAB-5861 | biostudies-arrayexpress
TranscriptomicsUC San Diego Friedmann Kang Neuronal Differentiation DSD3 SNM
The gene expression pattern of spherical neural masses (SNM) derived from HPRT knockdown murine D3 stem cells during neuronal differentiation to final neurons was invesitigated by RNA-Seq based gene expression analysis and the results were interpreted by GO, GSEA and signaling pathway analyses with ...
ORGANISM(S): Mus musculus 
2012-12-10 | E-GEOD-42662 | biostudies-arrayexpress
ProteomicsThe COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
In the context of studying the role of the COP9 signalosome (CSN) in neuroinflammation and ischemic neuronal damage, we studied the effect of the cullin NEDDylation state-modifying drugs MLN4924 and CSN5i-3 in BV2 microglial cells, an immortalized murine cell line featuring many of the characteristi...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044650 | Pride
Constitutive photomorphogenesis 9 signalosome (csn) Ischemic stroke Jab1 Csn5 Microglia Organoid 
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