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TranscriptomicsA primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson’s disease
The degenerative process in Parkinson’s disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in neuronal susceptibility warrants an amenable PD model that, in comparison to post-mortem human specimens, controls for environmental...
ORGANISM(S): Macaca fascicularis 
2023-11-19 | E-MTAB-13437 | biostudies-arrayexpress
GenomicsReversible suppression of autophagy in a mouse model reveals neuronal resilience
Reversible suppression of autophagy in a mouse model reveals neuronal resilience
PRJNA1453924 | ENA
ProteomicsACSS2 Upregulation Enhances Neuronal Resilience to Aging and Neurodegeneration
Epigenetic mechanisms, including histone acetylation, play a key role in learning and memory, with recent evidence of a role in neuronal function in Alzheimer’s disease and Related Dementia (ADRD). Acetyl-CoA sythetase 2 (ACSS2) is central to epigenetics and gene regulation, particularly in neurons,...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD048769 | Pride
Acss2 Aging Neuron Neurodegeneration 
GenomicsACSS2 upregulation enhances neuronal resilience to aging and neurodegeneration [RNA-seq]
ACSS2 upregulation enhances neuronal resilience to aging and neurodegeneration [RNA-seq]
PRJNA1072996 | ENA
GenomicsACSS2 upregulation enhances neuronal resilience to aging and neurodegeneration [Cut&Run]
ACSS2 upregulation enhances neuronal resilience to aging and neurodegeneration [Cut&Run]
PRJNA1072017 | ENA
GenomicsZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease
ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease
PRJNA819020 | ENA
TranscriptomicsNeuronal expression of bromodomain proteins alter neuronal health and peripheral protein homeostasis to promote longevity
Longevity and stress resilience require coordinated gene expression across tissues. We found that neuronal overexpression of the chromatin reader BET-1 in C. elegans extends lifespan and enhances stress resistance through cell non-autonomous signaling. Neuronal BET-1 triggers a neurotransmitter-depe...
ORGANISM(S): Caenorhabditis elegans 
2026-07-31 | E-MTAB-15906 | biostudies-arrayexpress
ProteomicsNeuronal metabolic rewiring promotesresilience to neurodegeneration caused by mitochondrial dysfunction
Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinj...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-03 | PXD019690 | Pride
Anaplerosis Labe-free Tmt Purkinje neurons Mitofusin 2 
ProteomicsPrefrontal cortical synaptoproteome profile combined with machine learning predict resilience towards chronic social isolation in rats
Chronic social isolation (CSIS), an animal model of depression, generates two stress-response phenotypes: CSIS-resilient and CSIS-susceptible. However, the molecular mechanism underlying resilience to CSIS remains unclear. We aimed to investigate the prefrontal cortical synaptoproteome profile betwe...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-23 | PXD047159 | Pride
Resilience Prefrontal cortex Proteomics Machine learning Chronic social isolation Synaptosome 
TranscriptomicsReversible suppression of autophagy in a mouse model reveals neuronal resilience
Impairments in intracellular quality control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aiming to slow neuronal deterioration, it remains unclear whether neuronal functions and intracellular quality can be restored once impaired. Here, we develo...
ORGANISM(S): Mus musculus 
2026-05-07 | GSE328108 | GEO
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