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ProteomicsChronic Midazolam Exposure on Neonates and Long-Term Neurodevelopment
About 1 in 10 U.S. newborns are born preterm and often require sedation, which may pose long-term neurodevelopmental risks. This study examined the effects of chronic exposure to midazolam (MDZ), a sedative commonly used in NICUs, using a rodent model. Researchers assessed physical, molecular, bioch...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-27 | PXD062940 | Pride
Midazolam Neurodevelopment 
ProteomicsPropagation of a rapid cell-to-cell H2O2 signal over long distances in a monolayer of cardiomyocyte cells
Cell-to-cell communication plays a cardinal role in the biology of multicellular organisms. H2O2 is an important cell-to-cell signaling molecule involved in the response of mammalian cells to wounding and other stimuli. We previously identified a signaling pathway that transmits wound-induced H2O2 c...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-24 | PXD047131 | Pride
Hydrogen peroxide Cell-to-cell Superoxide Signal transduction Proteomics Gap junction 
ProteomicsThe CRL3gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins
Giant axonal neuropathy (GAN) is caused by mutations in the GAN gene encoding for gigaxonin (GIG), which functions as an adaptor of the CUL3-RBX1-GIG (CRL3GIG) E3 ubiquitin ligase complex. The pathological hallmark of GAN is characterized by the accumulation of densely packed neurofilaments (NFs) in...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD042592 | Pride
Usp15 Gan Gigaxonin Neurofilament 
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
The Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and imm...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD069209 | Pride
Nanopig Tissue Plasma Lc-msms 
MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
UnknownDevelopment of an LC-MS/MS Method for ARV-110, a PROTAC Molecule, and Applications to Pharmacokinetic Studies.
Not available
S-EPMC8954769 | biostudies-literature
ProteomicsThe skeletal proteome of the feather star Anneissia japonica
Skeletal elements from the feather star Anneissia japonica were isolated and stripped of organic material. The skeleton was then demineralized and the occluded proteins isolated. The proteins were separated by SDS-PAGE and fractions were analyzed by LC-MS/MS. The results were compared to predicted p...
ORGANISM(S): Anneissia japonica 
2021-09-09 | PXD019526 | Pride
Anneissia japonica 
UnknownLong-Term Natural History of Microscopic Colitis: A Population-Based Cohort.
Not available
S-EPMC6775341 | biostudies-literature
ProteomicsAcute stress induces long-term metabolic, functional and structural remodeling of the heart
Takotsubo syndrome is a stress-induced cardiomyopathy with symptoms comparable to those of acute coronary syndrome but without coronary obstruction. Initially considered spontaneously reversible, the reversibility of takotsubo was challenged by epidemiological studies showing high morbi-mortality in...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-28 | PXD032667 | Pride
Tims tof pro Mouse heart takotsubo model Label-free quantification Stress-induced cardiomyopathy 
UnknownImprovement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine.
Not available
S-EPMC5595805 | biostudies-literature
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