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ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
The Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and imm...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD069209 | Pride
Nanopig Tissue Plasma Lc-msms 
ProteomicsIntroducing the Sinclair Nanopig™ model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment
he Nanopig™ model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential advantages for translational research. Here, we report initial characterization results using whole genome sequencing (WGS) and tissue-based proteomics, focusing on drug metabolism and immu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-08 | PXD068793 | Pride
Hepatic cyp450 Preclinical model Nanopig Whole genome sequencing Proteomics 
UnknownKTt-45, a T-type calcium channel blocker, acts as an anticancer agent by inducing apoptosis on HeLa cervical cancer cell line.
Not available
S-EPMC10716508 | biostudies-literature
MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
UnknownTiO2-enhanced fly ash for advanced treatment of persistent organics (POCs) in landfill leachate via hybrid ozonation–peroxymonosulfate: degradation efficiency and machine learning modeling
Not available
S-EPMC12379885 | biostudies-literature
ProteomicsThe CRL3gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins
Giant axonal neuropathy (GAN) is caused by mutations in the GAN gene encoding for gigaxonin (GIG), which functions as an adaptor of the CUL3-RBX1-GIG (CRL3GIG) E3 ubiquitin ligase complex. The pathological hallmark of GAN is characterized by the accumulation of densely packed neurofilaments (NFs) in...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD042592 | Pride
Usp15 Gan Gigaxonin Neurofilament 
TranscriptomicsComparison of low water potential (drought)-regulated gene expression in wild type (Col-0) and the hai1-2 (At5g59220) mutant
The Clade A PP2C Highly ABA-Induced1 (HAI1, At5g59220) is strongly up-regulated by low water potential in an ABA-dependent manner. Using knockout mutants of hai1, we found that HAI1 functions as a negative regulator of low water potential-induced proline and osmoregulatory solute accumulation. We ...
ORGANISM(S): Arabidopsis thaliana 
2012-02-03 | E-GEOD-35258 | biostudies-arrayexpress
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD028069 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
ProteomicsDifferential nuclear import sets the timing of protein access to the embryonic genome
During early embryonic cell divisions, the total nuclear volume doubles with each cycle. At a critical volume ratio between the nucleus and cytoplasm, embryos start transcribing their genome in a reproducible and sequential manner. However, the underlying molecular mechanism for these well-timed eve...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-30 | PXD036403 | Pride
Multiplexed quantitative proteomics Lc-ms Xenopus embryo Nucleocytoplasmic partitioning Zygotic gene activation Early embryogenesis Nuclear import 
UnknownMolecular Investigation of the p28 Gene of <i>Ehrlichia canis</i> in Infected Dogs From Ho Chi Minh City, Vietnam.
Not available
S-EPMC12517983 | biostudies-literature
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