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ProteomicsTop-down detection of oxidative protein footprinting by Collision-Induced Dissociation, Electron-Transfer Dissociation and Electron-Capture Dissociation
Fast photochemical oxidation of proteins (FPOP) footprinting is a structural mass spectrometry method that maps proteins by fast and irreversible chemical reactions. The position of oxidative modification reflects solvent accessibility and site reactivity and thus provides information about protein ...
ORGANISM(S): Bos taurus (Bovine) Equus caballus (Horse) 
2023-07-20 | PXD031926 | Pride
Electron-transfer dissociation Fast photochemical oxidation of proteins Top-down Collision-induced dissociation Mass spectrometry. Electron-capture dissociation 
ProteomicsCellular senescence escape and antiviral response discriminate glioblastoma from lower grade gliomas
Cellular senescence is a negative prognostic indicator in glioblastoma (GB). However, the specific cell types exhibiting senescence and the molecular mechanisms by which senescent cells (SCs) contribute to GB pathogenesis remain unknown. We performed multi-omics integration of publicly available GB ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD071225 | Pride
ProteomicsAntibody Characterisation using FFAP
Modern therapeutic approaches, especially for cancer and certain autoimmune disorders, evolved and have started to frequently rely on monoclonal antibodies (mAb) or other recombinantly prepared biomolecules (biopharmaceuticals) instead of on small molecules. The mAb treatment is effective but comes ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044326 | Pride
Covalent labeling Protein structure Mass spectrometry Ffap Togni agents 
ProteomicsUtilization of high-resolution mass spectrometry and data-independent analysis to track the monoclonal antibody spatial stability
Chemical cross-linking coupled with mass spectrometry (CXMS) offers the distance constraints critical for building the structural model of protein and protein complexes and understanding dynamics of biological systems. Originally developed for protein structural models, CXMS has evolved into method ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Equus caballus (Horse) 
2025-07-08 | PXD060322 | Pride
Antibody Mass spectrometry Protein structure Chemical cross-linking Data-independent analysis Stable isotopes 
ProteomicsLinX - software for evaluation of CX-MS data
Chemical cross-linking mass spectrometry data from analysis of N14/N15 labeled proteins
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-03-11 | PXD023522 | Pride
Linx Chemical cross-linking Mass spectrometry Ledg Foxo4 Nkrp1b 
ProteomicsFast Fluoroalkylation of Proteins Uncovers Structure and Dynamics of Biological Macromolecules
Stable covalent labeling of proteins in combination with mass spectrometry has been established as a complementary technique to classical structural methods, such as X Ray, NMR, or Cryo-EM used for protein structure determination. Although the current stable covalent labeling techniques enable to mo...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD027310 | Pride
Radical labeling Mass spectrometry Protein footprinting Conformational changes Fluoroalkylation Hyperva-lent iodine reagents Protein structure Togni reagents Protein fingerprinting Epitope mapping Protein surface mapping Radicals Proteomics Interactomics Trifluoromethylation 
ProteomicsThe novel insight into human HSC70 structure by CX-MS and molecular modelling
Heat shock cognate protein 70 (HSC70) is a 71 kDa molecular chaperone belonging to the ubiquitous family of heat shock proteins 70 (Hsp70). The representatives of this protein family are molecular machines with ATPase activity facilitating correct folding of spatial protein structure, both in normal...
ORGANISM(S): Homo sapiens (Human) 
2026-08-28 | PXD072234 | Pride
Structural mass spectrometry Protein folding Chaperone Homo-oligomerization 
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