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ProteomicsNucleocytoplasmic O-Man glycoproteome
Dynamic cycling of N-Acetylglucosamine (GlcNAc) on serine (Ser) and threonine (Thr) residues (O-GlcNAcylation) is an essential process in all eukaryotic cells except yeast, e.g Saccharomyces cerevisiae. O-GlcNAcylation modulates signaling and cellular processes in an intricate interplay with protein...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) Schizosaccharomyces pombe 
2015-12-08 | PXD002924 | Pride
O-glycoproteomics Saccharomyces cerevisiae 
ProteomicsCardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption
Protein kinase R (PKR) is a key antiviral kinase activated by binding double-stranded RNA (dsRNA) produced during viral replication. Upon activation, PKR phosphorylates eIF2α, leading to the inhibition of translation and viral replication. However, many viruses have evolved mechanisms to counteract ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD066206 | Pride
Nucleocytoplasmic traffic Pkr Nucleocytoplasmic trafficking disorder (nctd) Cardiovirus Stress granules. Picornavirus Nucleoli Double-stranded rna Eif2ak2 
GenomicsTMEM63B Regulates Nucleocytoplasmic Transport and Placental Development
TMEM63B Regulates Nucleocytoplasmic Transport and Placental Development
PRJNA1226629 | ENA
GenomicsTANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning
TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning
PRJNA1182235 | ENA
GenomicsNucleocytoplasmic mRNA redistribution in ALS motor neurons and is reversed by VCP ATPase inhibition
Nucleocytoplasmic mRNA redistribution in ALS motor neurons and is reversed by VCP ATPase inhibition
PRJNA883641 | ENA
TranscriptomicsNucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer
Biological oscillations are observed at many levels of cellular organization. In the social amoebae Dictyostelium discoideum, starvation-triggered multicellular development is organized by periodic cAMP waves, which provide both chemoattractant gradients and developmental signals. We report that Gta...
ORGANISM(S): Dictyostelium discoideum 
2014-04-15 | E-GEOD-54866 | biostudies-arrayexpress
ProteomicsRNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1 - a major mRNA synthesis and decay factor. Here we show that nucleocytoplasmic shuttling of several mRNA decay factors plays a key role in determining both mRNA synthesis and decay...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-09-19 | PXD036414 | Pride
Nucleocytoplasmic shuttling Xrn1 Mrna decay 
ProteomicsNucleocytoplasmic transport and membrane growth control nuclear size
How cells control the overall size of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size that is proportional to cellular size, resulting in a constant ratio between the nuclear and cellular volumes (N/C ratio). To shed light on...
ORGANISM(S): Schizosaccharomyces pombe 
2017-06-05 | PXD004530 | Pride
Nuclear cell ratio Nuclear size Silac 
ProteomicsCardioviruses’ leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Proteins from unrelated pathogens, including some RNA or DNA viruses and bacteria can recruit and activate cellular p90-ribosomal protein S6 kinases (RSKs) through a common linear motif. Data suggested a model where pathogens' proteins act to dock the recruited RSKs toward specific substrates, which...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD034604 | Pride
P90 ribosomal s6 kinases Picornavirus Nucleocytoplasmic traffic Rsk Cardiovirus Phosphorylation Yopm Nucleoporins Linear motifs 
ProteomicsDisruption of nucleocytoplasmic trafficking as a cellular senescence driver
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This reduction could be explained by disrupted nuclear transmission of signals. However, this hypothesis required more evidence to complete as a new modality of cellular senescence. Proteomic analysis of the cytoplasmic a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-18 | PXD025618 | Pride
Nuclear barrier Cellular senescence Replicative senescence Eukaryotic aging Nucleocytoplasmic trafficking 
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