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MetabolomicsThe Streptomyces-derived nucleoside Guvermectin simultaneously promotes plant growth and immunity

This study investigates the dual role of the Streptomyces-derived nucleoside Guvermectin (GV) in promoting plant growth and enhancing disease resistance. Multiomics analysis revealed that GV reprograms phenylalanine metabolism, leading to the accumulation of antimicrobial flavonoids. A key UDP-gl...

2026-01-31 | MTBLS13810 | MetaboLights
ProteomicsNucleoside Analogues are Potent Inducers of Bacterial Mutagenesis
Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of antimicrobial resistance (AMR). Here we have examined nucleoside analogues (NAs) ...
ORGANISM(S): Escherichia coli 
2021-07-15 | PXD025370 | Pride
Na -clamp Tls Mdr Pol v Nrtis Sos Amr 
ProteomicsNucleosides and Oligonucleotides analysis using LC-MS/MS in mouse liver
Here, we establish a sequence-resolved mouse liver small-RNA epitranscriptomic database by integrating nucleoside-level modification discovery with complementary RNase T1 and RNase A LC–MS/MS oligonucleotide mapping, enabling high-confidence modification-site annotation across tRNAs, 5S and 5.8S rRN...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-31 | PXD082484 | Pride
Mouse Liver Oligonucleotide Nucleoside Lc-ms/ms 
TranscriptomicsTranscription profiling of human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon)
Affymetrix U95Av2 expression data from human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon). Entries contain the search terms glycosylase, phosphorylase, cytochrome or nucleoside, which were relevant to our search for enzymes capable of cleaving...
ORGANISM(S): Homo sapiens 
2007-06-21 | E-GEOD-1862 | biostudies-arrayexpress
MetabolomicsVirus-encoded glycosyltransferases hypermodify DNA with diverse glycans

Enzymatic modification of DNA nucleobases can coordinate gene expression, nuclease protection or mutagenesis. We recently discovered a clade of phage-specific cytosine methyltransferase (MT) and 5-methylpyrimidine dioxygenase (5mYOX) enzymes that produce 5-hydroxymethylcytosine (5hmC) as a precur...

2024-08-22 | MTBLS10724 | MetaboLights
ProteomicsDual protein kinase/ nucleoside kinase modulat ors for rationally designed polypharmacology
Masitinib, a highly selective protein kinase inhibitor, can sensitise gemcitabine-refractory cancer cell lines when used in combination with gemcitabine. A reverse proteomic approach has identified the target responsible for this sensitisation: the deoxycytidine kinase (dCK). Masitinib, as well as o...
ORGANISM(S): Homo sapiens (Human) 
2017-11-13 | PXD007765 | Pride
Human Ltq-velos-orbitrap Labelfree 
TranscriptomicsLMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells
[original title] LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells and minimal toxicity for normal hematopoietic cells. LMP-420 induces cytotoxicity and apoptosis to CLL cells in vitro without any negative effects to normal immune cells...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-20211 | biostudies-arrayexpress
TranscriptomicsGene expression in wild type and mENT1 knock out mice
To investigate the functional importance of a nucleoside transporter, the mENT1 (Slc29a1) was knocked out in mice. The gene expression profile was compared between wildtype and mENT1 knock out mice in two tissues. RNA was isolated from heart and kidney from 3 mENT1 knockout and 3 wildtype (FVB/N) mi...
ORGANISM(S): Mus musculus 
2011-04-27 | E-GEOD-22565 | biostudies-arrayexpress
TranscriptomicsThe search for enzymes responsible for metabolism of nucleoside analogs
Affymetrix U95Av2 expression data from human intestinal cells (Caco-2) and tissues from all intestinal segments (duodenum, jejunum, ileum, colon). Entries contain the search terms "glycosylase, phosphorylase, cytochrome or nucleoside," which were relevant to our search for enzymes capable of cleavin...
ORGANISM(S): Homo sapiens 
2005-10-30 | GSE1862 | GEO
GenomicsBacterial nucleoside catabolism controls quorum sensing and commensal-to-pathogen transition in the Drosophila gut
Bacterial nucleoside catabolism controls quorum sensing and commensal-to-pathogen transition in the Drosophila gut
PRJNA588975 | ENA
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