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ProteomicsSelective degradation of platelet BTK by the PROTAC NX-5948
This study presents a tandem mass tag (TMT)–based quantitative proteomic analysis of human platelets treated with the BTK degraders NX-2127 or NX-5948, or vehicle control (DMSO). Washed platelet lysates from three independent biological replicates per condition were digested with trypsin, labelled w...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD072863 | Pride
Human Nx-2127 Quantitative proteomics Nx-5948 Sps-ms3 Tmt Btk Protac Thrombosis Platelets 
UnknownBreakthroughs in treatment for hematological malignancies: latest updates on molecular glue, PROTACs and RNA degraders from ASH 2024.
Not available
S-EPMC11884154 | biostudies-literature
Genomics
Molecular and Structural Basis of Pan-Resistance to BTK Degraders and Inhibitors
PRJNA1422701 | ENA
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