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ProteomicsSelective degradation of platelet BTK by the PROTAC NX-5948
This study presents a tandem mass tag (TMT)–based quantitative proteomic analysis of human platelets treated with the BTK degraders NX-2127 or NX-5948, or vehicle control (DMSO). Washed platelet lysates from three independent biological replicates per condition were digested with trypsin, labelled w...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD072863 | Pride
Human Nx-2127 Quantitative proteomics Nx-5948 Sps-ms3 Tmt Btk Protac Thrombosis Platelets 
UnknownMutation in Bruton Tyrosine Kinase (BTK) A428D confers resistance To BTK-degrader therapy in chronic lymphocytic leukemia.
Not available
S-EPMC11286506 | biostudies-literature
ProteomicsKinase Impaired BTK Mutations Are Susceptible to Clinical Stage BTK and IKZF1/3 Degrader NX-2127
Here we identify that drug-resistant BTK mutations occur in distinct enzymatic classes, some of which render BTK enzymatically impaired while conferring novel protein-protein interactions to sustain B-cell receptor (BCR) signaling.
ORGANISM(S): Homo sapiens (Human) 
2023-12-09 | PXD039012 | Pride
Kinase dead Btk Phosphoproteomics 
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