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ProteomicsUnusual cardiac myosin heavy chain post-translational modifications with systolic heart failure
In the present study, we aimed at defining whether cardiac myosin heavy chain (MYH7) post-translational modifications would be altered in systolic heart failure. For that, we had access to septal tissue from donors and from patients with non-genetic dilated cardiomyopathy or with ischemic cardiomyop...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076695 | Pride
Heart failure  systolic dysfunction  myh7  myosin 
ProteomicsEffect of Mavacamten on skeletal muscle fibre proteome in nemaline myopathy
Nemaline myopathy (NM) is a genetic muscle disorder, notably caused by mutations in the NEB gene (NEB-NM). Here we investigated the efficacy of a four-week Mavacamten (myosin ATPase inhibitor) treatment using a NEB-NM mouse model. After the four weeks, soleus muscles were extracted, muscle fibres we...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-14 | PXD051963 | Pride
Skeletal muscle cell  nemaline myopathy  nebulin  mavacamten 
ProteomicsAberrant troponin post-translational modifications with TNNT1 mutations
TNNT1 mutations are associated with congenital myopathies. Here, we aimed to investigate whether troponin T post-translational modifications would be affected by the mutations. For that, we used muscle biopsy specimens from patients with TNNT1 mutations and controls. We then defined the nature and l...
ORGANISM(S): Homo sapiens (Human) 
2025-01-08 | PXD054504 | Pride
Troponin Genetic disorder Skeletal muscle 
ProteomicsDefining the cardiac acetylome in type 2 diabetes
Here, we aimed to assess the effect of type 2 diabetes on lysine acetylation levels of cardiac muscles. We used human left ventricular samples from human donors with and without diabetes and investigated the acetylome.
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD068671 | Pride
Heart  acetylome  type 2 diabetes 
ProteomicsIdentification of cardiac myosin heavy chain post-translational modifications in hibernating grizzly bears
Mammal hibernation is a physiological process with unclear molecular mechanisms. Here, we aimed to investigate whether cardiac myosin heavy chain post-translational modifications would be affected by hibernation. For that, we used cardiac left ventricle specimens from active and hibernating adult gr...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2025-05-07 | PXD054499 | Pride
Bear Ptm Myosin 
TranscriptomicsGene expression and muscle fiber function in a porcine ICU model
Background: Skeletal muscle wasting and impaired muscle function in response to mechanical ventilation and immobilization in intensive care unit (ICU) patients are clinically challenging partly due to (i) the poorly understood intricate cellular and molecular networks; and (ii) the unavailability of...
ORGANISM(S): Sus scrofa 
2009-08-31 | E-GEOD-16348 | biostudies-arrayexpress
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